[Expression and significance of vascular permeability factor in nasal polyps].

OBJECTIVE

To study the expression and significance of vascular permeability factor(VPF) in nasal polyps.

METHODS

Expression of VPF and its receptor flk-1 in nasal polyps from 9 patients and inferior turbinates from 8 patients with chronic rhinitis were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope.

RESULTS

The VPF positivity in vascular endothelium and in gland cell was significantly higher in nasal polyps than in inferior turbinates (P < 0.01 and P < 0.05, respectively). The flk-1 labeling index of vascular endothelium was significantly higher in nasal polyps than that in inferior turbinates (P < 0.01).

CONCLUSIONS

VPF may play a key role in the formation of heavy edema of nasal polyps.