African Health Sciences 2018-Jun
How do Spondias mombin L (Anacardiaceae) leaves extract increase uterine smooth muscle contractions to facilitate child birth in parturient women?
רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
הקישור נשמר בלוח
מילות מפתח
תַקצִיר
Background
Spondias mombin L. (Anacardiaceae) leaves were used in Togolese folk to treat dystocia, expel placenta and manage post-partum hemorrhage during child birth.Objectives
This study aimed to establish how the extract of S. mombin leaves increase uterine smooth muscle contractions relevant to its traditional use to facilitate child birth.Results
S. mombin leaves extract increased uterine spontaneous contractions. This effect was reduced by indomethacin (2 × 10-6 M), yohimbine (2 × 10-6 M) and 2-aminoethoxydiphenyl borate (2-APB) (5 × 10-5 M), but not by atropine (3.45 × 10-8 M) and cholesterol (2.5 mg/ml).Conclusion
The pharmacological justification for the traditional use of S. mombin leaves to treat dystocia and expel placenta was that its hydro-ethanolic extract induced prostaglandins release, α2-adrenoceptors stimulation, calcium release from internal stores and lifted inhibitory effect of cholesterol on uterine contractions in order to increase uterine smooth muscle contractions.