In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer.

Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicinesfor cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance ofpracticing natural medicines and developing natural product based drugs for cancer treatment. Recently we reportedan anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells invitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extractof A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed andIn vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerateddifferent doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar todoxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion:Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.