[The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats].

OBJECTIVE

To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action.

METHODS

Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI).

RESULTS

Seed oil of Hippophae rhamnides 0.7 and 0.35 g.kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats.

CONCLUSIONS

These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.