[The significance of microvessel density and CD34 expression in nasal polyps].

OBJECTIVE

To study the clinicopathologic significance of microvessel density (MVD) and the expression of CD34 in human nasal polyps.

METHODS

Using Elivision Plus immunohistochemistry method. Thirty cases of normal inferior turbinate, 60 cases of nasal polyps were stain with CD34.

RESULTS

MVD of CD34 marker showed higher in the group of nasal polyps than in the group of normal inferior turbinate (P <0.01). MVD in nasal polyps type II phase 3 and type III was higher than that in the nasal polyps type II phase (P < 0.01).

CONCLUSIONS

MVD is closely related with the formation edema and development of nasal polyps. Angiogenesis may play an important role in the development of nasal polyps.