Association of overweight and obesity with cardiovascular risk factors in patients with atherosclerotic diseases

Background: The aim of this study was to compare demographic, clinical and biochemical characteristics, including inflammatory markers, according to the nutritional status of patients with verified atherosclerotic disease.

Methods: This cross-sectional study involved 1045 consecutive patients with verified carotid disease or peripheral arterial disease (PAD). Anthropometric parameters and data on cardiovascular risk factors and therapy for hypertension and hyperlipidemia were collected for all participants.

Results: Carotid disease was positively and PAD was negatively associated with body mass index (BMI). Negative association between obesity and PAD was significant only in former smokers, not in current smokers or in patients who never smoked. Overweight and general obesity were significantly related to metabolic syndrome (p < 0.001), lower values of high - density lipoprotein cholesterol (p < 0.001), increased triglycerides (p < 0.001), hyperglycemia (p < 0.001), self-reported diabetes (p < 0.001), hypertension (p < 0.001), high serum uric acid (p < 0.001), increased high sensitivity C-reactive protein (p = 0.020) and former smoking (p = 0.005) after adjustment for age, gender and type of disease. Antihypertensive therapy seems to be less effective in patients who are overweight and obese.

Conclusions: In conclusion, overweight and general obesity were significantly related to several cardiovascular risk factors.

Uvod: Cilj ove studije je bio da se porede demografske, kliničke i biohemijske karakteristike, uključujući inflamatore markere, sa stanjem uhranjenosti kod pacijenata obolelih od aterosklerotske bolesti.

Metode: Ova studija preseka je obuhvatila 1045 pacijenata sa dijagnostikovanom karotidnom i perifernom arterijskom bolešću. Antropometrijski parametri i podaci o faktorima rizika za kardiovaskularne bolesti i terapiju za hipertenziju i hiperlipidemiju su prikupljeni od svih pacijenata.

Rezultati: Karotidna bolest je bila povezana, dok periferna arterijska bolest nije bila povezana sa indeksom telesne mase (ITM). Negativna veza između gojaznosti i periferne arterijske bolesti je zabeležena samo kod bivših pušača, a ne i kod sadašnjih i kod onih koji nisu nikada pušili. Predgojaznost i gojaznost su bile značajno povezane sa metaboličkim sindromom (p < 0,001), smanjenim nivoom HDL holesterola (p < 0,001), povišenim nivoom triglicerida (p < 0,001), hiperglikemijom (p < 0,001), šećernom bolešću (p < 0,001), hipertenzijom (p < 0,001), povišenim nivoom mokraćne kiseline (p < 0,001), povišenim nivoom ultra senzitivnog C-reaktivnog proteina (p = 0,020) bivšim pušačima (p = 0,005) posle prilagođavanja na godine, pol i vrstu bolesti. Antihipertenzivna terapija izgleda da ima sma njen efekat kod pacijenata sa prekomernom telesnom masom i gojaznošću.

Zaključak: Prekomerna telesna masa i gojaznost opšteg tipa su bile značajno povezane sa nekoliko faktora rizika za kardiovaskularne bolesti.

Keywords: atherosclerosis; carotid disease; obesity; peripheral arterial disease; risk factors.