Journal of Internal Medicine 2020-Apr
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease.
רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
הקישור נשמר בלוח
מילות מפתח
תַקצִיר
RESULTS
During a median follow-up of 4.9 years, 336 (8.2%) patients experienced an AMI. The age- and sex-adjusted hazard ratio (HR) (95% CI) comparing the 4th vs. 1st TML quartile was 2.19 (1.56-3.09). Multivariable adjustment for traditional cardiovascular risk factors and indices of renal function only slightly attenuated the risk estimates (HR [95% CI] 1.79 [1.23-2.59]), which were particularly strong among patients with riboflavin levels above the median (pint =0.035). Plasma TML and TMAO were strongly correlated (rs =0.41; p<0.001); however, plasma TMAO was not associated with AMI risk in adjusted analyses (HR [95% CI] 0.81 [0.58-1.14]). No interaction between TML and TMAO was observed.