Carboxylic acid / הקאה

Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals. UK Patent Applications, GB Nos. 2100259A and 2125398A describe benzoates and

Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

FIELD OF THE INVENTION This invention relates to derivatives of novel 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinyl-6-carboxylic acid useful as potent and selective anti-emetic or anti-nausea agents, or both, for pre-operative, intra-operative, and post-operative use. BACKGROUND OF THE INVENTION Nausea

Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION This invention is concerned with compounds of structural formula I: ##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --S--CH.sub.2 --, --CH.sub.2 --S--, --S-- or --O--, and R is a 5- or 6-membered nitrogen heterocyclic

Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION This invention is concerned with compounds of structural formula I: ##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --S--CH.sub.2 --, --CH.sub.2 --S--, --S-- or --O--, and R is a 5- or 6-membered nitrogen heterocyclic

Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION 1. Field of Invention Novel 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.2.1]octanes and 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.3.1]nonanes are coupled with aryl carboxylic acids to obtain the corresponding amides and esters. These novel amides and esters,

Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION 1. Field of Invention Novel 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.2.1]octanes and 5-aminomethyl-and 5 -hydroxymethyl-1-azabicyclo[3.3.1]nonanes are coupled with aryl carboxylic acids to obtain the corresponding amides and esters. These novel amides and esters,

5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT.sub.3 antagonists

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION A variety of agents are presently under development as potential treatments for migraine headaches. For example, MDL-72222 (tropine 3,5-dichlorobenzoate) is reported to block the M-receptors for 5-hydroxytryptamine (5-HT), now referred to as 5-HT.sub.3 receptors, thereby

Certain 2,3-dihydro-2;2-dimethyl-benzothiophene carboxylic acids which are intermediates

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION A variety of agents are presently under development as potential treatments for migraine headaches. For example, MDL-72222 (tropine 3,5-dichlorobenzoate) is reported to block the M-receptors for 5-hydroxytryptamine (5-HT), now referred to as 5-HT.sub.3 receptors, thereby

Benzimidazolone carboxylic acid derivatives

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION This invention relates to benzimidazolone carboxylic acid derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives

Benzimidazolone carboxylic acid derivatives

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION This invention relates to benzimidazolone carboxylic acid derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives

Benzimidazolone carboxylic acid derivatives

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION This invention relates to benzimidazolone carboxylic acid derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of certain bicyclic carboxylic acids

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

carboxylic acid/הקאה

Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis

Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid

Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds

Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents

Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents

5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT.sub.3 antagonists

Certain 2,3-dihydro-2;2-dimethyl-benzothiophene carboxylic acids which are intermediates

Benzimidazolone carboxylic acid derivatives

Benzimidazolone carboxylic acid derivatives

Benzimidazolone carboxylic acid derivatives

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

Meso-azacyclic amides of certain bicyclic carboxylic acids

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