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carboxylic acid/infarction

הקישור נשמר בלוח
מאמריםניסויים קלינייםפטנטים
15 תוצאות

Process for imaging cardiac infarcts

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
BACKGROUND OF THE INVENTION Radiopharmaceuticals are widely used to evaluate cardiac function. Among the radioactive agents employed are, for example, .sup.99m Tc-labeled human serum albumin and .sup.99m Tc-labeled red blood cells for determination of cardiac blood volume, left ventrical wall

4,5-dihydro-[1H]-benz[g]indazole-3-carboxylic acid derivatives

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
CROSS-REFERENCE This application is a 371 of PCT/JP98/02758 filed Jun. 22, 1998, which is based on Japanese Application No. 199,128/97 filed Jul. 10, 1997. TECHNICAL FIELD This invention relates to novel 4,5-dihydro-[1H]-benz[g]-indazole-3-carboxylic acid derivatives. More particularly, it relates

Branched carboxylic acid compound and use thereof

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
TECHNICAL FIELD The present invention relates to a compound, which is useful for medicinal drug, represented by formula (I): ##STR00002## wherein all symbols have the same meanings as described below, use thereof, and a pharmaceutical composition comprising the same as an active

Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The present invention relates to novel substituted vinylcarboxylic acid derivatives which possess the action to inhibit specifically the thromboxane A.sub.2 (TXA.sub.2) synthetase. TXA.sub.2 is a metabolite of arachidonic acid and has the platelet aggregating action. Therefore, it has been known
FIELD OF THE INVENTION This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,

7[4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
FIELD OF THE INVENTION This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,

Sulfur containing trialkoxybenzoylamino carboxylic acids

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The invention is directed to compounds of the formula: ##STR2## wherein: A is a straight or branched chain alkylene or alkylidene radical having 2 to 5 carbon atoms and which is substituted by an alkylthio group having 1 to 4 carbon atoms, a carboxymethyl thio group, a carboxyethyl thio group, an

Sulfur containing trialkoxybenzoylamino carboxylic acids

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The invention is directed to compounds of the formula: ##SPC2## Wherein: A is a straight or branched chain alkylene or alkylidene radical having 2 to 5 carbon atoms and which is substituted by an alkylthio group having 1 to 4 carbon atoms, a carboxymethyl thio group, a carboxyethyl thio group, an

Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The present invention relates to compounds of the formula I, ##STR00002## wherein A, Y, Z, R.sup.20 to R.sup.22 and R.sup.50 have the meanings indicated below, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2

Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The present invention relates to compounds of the formula I, ##STR00002## wherein A, Y, Z, R.sup.20 to R.sup.22 and R.sup.50 have the meanings indicated below, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2

Carboxylic acid derivatives and drugs containing the same as the active ingredient

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
TECHNICAL FIELD The present invention relates to carboxylic acid derivatives and pharmaceutical compositions comprising the same as an active ingredient. More specifically, the present invention relates to (1) carboxylic acid derivatives represented by formula (I) ##STR00002## prodrugs thereof,

Substituted-phthalazone 7-carboxylic acid and salts and process for preparing same

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to novel phthalazone derivatives and more particularly to compounds of the formula ##STR2## wherein R.sup.4 represents a carbamoyl (--CONH.sub.2) group, a dialkylaminoalkylcarbamoyl group, a hydroxyalkylcarbamoyl
FIELD OF THE INVENTION This invention relates to new pharmaceutical preparations and the use thereof for the treatment of various pathophysiological diseases including acute myocardial infarction, left ventricular dysfunction without overt heart failure, congestive heart failure, angina pectoris,

(4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
BACKGROUND OF THE INVENTION The present invention relates to (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment. The compounds of the present invention are inhibitors of zinc metalloendopeptidases, especially

Inhibitor of ischemic disorders

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
RELATED APPLICATIONS This application claims the priority of Japanese Patent Application No. 2007-225021 filed on Aug. 31, 2007, which is incorporated herein by reference. FIELD OF THE INVENTION The present invention relates to the pharmaceuticals useful for the treatment and prevention of the
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