catharanthus/נגד סרטן

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עמוד 1 מ 160 תוצאות

Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Catharanthus roseus produces low levels of two dimeric terpenoid indole alkaloids, vinblastine and vincristine, which are widely used in cancer chemotherapy. The dimerization reaction leading to alpha-3',4'-anhydrovinblastine is a key regulatory step for the production of the anticancer alkaloids in

Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Throughout the history of human civilizations, cancer has been a major health problem. Despite the advancements made by modern medical sciences, complete treatment or removal of cancerous cells is still a challenging task. Vinblastine, an alkaloid obtained from Catharanthus roseus (L.) G.

Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Camptothecin (CPT) belongs to a group of monoterpenoidindole alkaloids (TIAs) and its derivatives such as irinothecan and topothecan have been widely used worldwide for the treatment of cancer, giving rise to rapidly increasing market demands. Genes from Catharanthus roseus encoding strictosidine

Anticancer drugs from traditional toxic Chinese medicines.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Many anticancer drugs are obtained from natural sources. Nature produces a variety of toxic compounds, which are often used as anticancer drugs. Up to now, there are at least 120 species of poisonous botanicals, animals and minerals, of which more than half have been found to possess significant

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Antitumor substances related to vinblastine and vincristine are exclusively found in the Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family, and continue to be extensively used in cancer chemotherapy. Although in high demand, these valuable compounds only

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis could provide an additional source of this drug. However, the chemistry underlying vinblastine synthesis makes

Catharanthus alkaloids XXXVII. 16-Epi-Z-isositsirikine, a monomeric indole alkaloid with antineoplastic activity from Catharanthus roseus and Rhazya stricta.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

16-Epi-Z-isositsirikine (1) has been isolated from the leaves of Catharanthus roseus and Rhazya stricta and identified through a combination of spectral interpretation and chemical correlation. The compound displayed antineoplastic activity in the KB test system in vitro and the P-388 test system in

A vacuolar class III peroxidase and the metabolism of anticancer indole alkaloids in Catharanthus roseus: Can peroxidases, secondary metabolites and arabinogalactan proteins be partners in microcompartmentation of cellular reactions?

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Plants possess a unique metabolic diversity commonly designated as secondary metabolism, of which the anticancer alkaloids from Catharanthus roseus are among the most studied. Recently, in a classical function-to-protein-to-gene approach, we have characterized the main class III peroxidase (Prx)

Natural products of plant origin as anticancer agents.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Natural products have been used as effective remedies for the treatment of various ailments. Numerous plant products in the form of decoction, tincture, tablets and capsules have been clinically used for the treatment of different kinds of cancer. This review covers some of the important plants with

[New antitumor derivatives of vinblastine].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The alkaloids of Catharanthus roseus vincristine 1 and vinblastine 2 are widely used in the chemotherapy of cancer. Their nitro-derivatives have also antitumour activity [2]. The dinitro-derivatives 4, 6-9 were prepared for pharmacological investigation. Some new hydroxymethyl derivatives 12-14,

Poisoning the spindle: serendipity and discovery of the anti-tumor properties of the Vinca alkaloids.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

In 1995, Canadian scientists Robert Noble and Charles Beer were inducted into the Canadian Medical Hall of Fame for their 1950s "discovery" of Vinblastine. Their "chance" finding of an anticancer drug in the leaves of the periwinkle plant (Vinca rosea, Linn.), is used to explore the historical issue

Isolation of Cells Specialized in Anticancer Alkaloid Metabolism by Fluorescence-Activated Cell Sorting.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Plant specialized metabolism often presents a complex cell-specific compartmentation essential to accomplish the biosynthesis of valuable plant natural products. Hence, the disclosure and potential manipulation of such pathways may depend on the capacity to isolate and characterize specific cell

Screening of Plants Used as Traditional Anticancer Remedies in Mkuranga and Same Districts, Tanzania, Using Brine Shrimp Toxicity Bioassay.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Inadequate specialized cancer hospitals and high costs are contributing factors that delay cancer patients from accessing health care services in Tanzania. Consequently, majority of patients are first seen by Traditional Health Practitioners (THPs) before they access specialized

The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell-penetrating peptide.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Some Vinca alkaloids (eg, vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new

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