This group of patients will receive single high dose of vitamin D (Cholecalciferol) dissolved in 45 ml of fresh milk (Nestle)

This group of patients will receive placebo - 45 ml of fresh milk (Nestle) so that the amount, color, smell, taste etc will be the same as that of experimental drug)

Vitamin D Deficiency

Critical Illness

400000 international Units of cholecalciferol will be dissolved in 45 ml of fresh milk (Nestle) and it will be given to interventional group patients through enteral route within 24 hours of ICU admission as a single dose.

Cholecalciferol

45 ml of Nestle milk will given to patients assigned as placebo

Milk (Nestle)

King Abdullah Medical City, Holy Capital

Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.

Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency in Intensive Care Unit- A Randomized Controlled Trial.

as evidenced by microbiological culture and sensitivity reports from samples taken from patients blood, sputum,urine and body fluids.

as evidenced by invasive blood pressure monitoring during ICU stay.

How long the patient will stay in Hospital

It will be assessed by rising serum creatinine level and decreasing urine out put per hour.

as evidenced by neurological deficit and CT sacn/MRI findings

It will be assessed by decreasing hemoglobin levels and endoscopic findings.

including, acute kidney injury, Myocardial Infarction, Cerebrovascular accidents, upper or lower gastro intestinal bleed)

Asiah Rugaan

Consultant and Head of Department - Intensive Care Unit

King Abdullah Medical City

The group who receive spironolactone, the dose employed will be 25 mg each other day and titrated to 25 mg daily according to potassium.

Renal Failure

Spironolactone

Hospital of the Medical School of Botucatu

Effects of Spironolactone in Dialysis

Assessment of the Effects of the Combination of Spironolactone to Conventional Pharmacotherapy in Dialysis Patients

The reduction of left ventricular hypertrophy will be measured by echocardiography, blood pressure monitoring residential and pulse wave velocity.

Measurement of serum potassium and other routine laboratory parameters pertaining to the hemodialysis unit of the Hospital of the Medical School of Botucatu - UNESP.

Greicy Mara Mengue Feniman De Stefano

UPECLIN HC FM Botucatu Unesp

Haemodialysis

dialysis fluid composition for Citrate (C) and Acetate (A): acetate [3.0 mmol/L in A and 0.3 in C], citrate [0 mmol/L in A and 0.8 in C]

cellulose/שבץ מוחי

Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.

Effects of Spironolactone in Dialysis

Citrate- Versus Acetate-Based Dialysate in Bicarbonate Haemodialysis: Consequences on Haemodynamics, Coagulation, Acid-Base Status and Electrolytes

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע