The invention relates to a method of developing a main proteinase SARS inhibitor. Human coronaviruses are major causes of upper respiratory tract illnesses in humans, in particular, the common cold. Recent investigations have shown that a novel coronavirus causes the Severe Acute Respiratory Syndrome (SARS), a disease that is characterized by high fever, malaise, rigor, headache, non-productive cough or dyspnea, which is rapidly spreading. Within the scope of the invention, based on the structural analysis of the binding mode of the SARS M.sup.pro enzyme, a group of prototype inhibitors is provided that acts as suitable drugs targeting a majority of viral infections of the respiratory tract, including SARS.

Universitat zu Luebeck

Crystal structure of human coronavirus 229E main proteinase and uses for developing SARS inhibitors

The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.

Chan; Phillip P.

Capponi; Vincent J.

Golobish; Thomas D.

Ali; Humayra Begum

CytoSorbents Corporation

Polymeric sorbent for removal of impurities from whole blood and blood products

The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.

dyspnea/חום

Crystal structure of human coronavirus 229E main proteinase and uses for developing SARS inhibitors

Polymeric sorbent for removal of impurities from whole blood and blood products

Polymeric sorbent for removal of impurities from whole blood and blood products

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע