flueggea suffruticosa/סרטן

הקישור נשמר בלוח

מאמריםניסויים קלינייםפטנטים

בחר סוג מיון

13 תוצאות

L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

L-securinine is a natural product extracted and isolated from the leaf of dried Securinega suffruticosa. The aim of the present study was to explore the effects of L-securinine on proliferation, and the methylation profile of the dickkopf-related protein 1 (DKK1) gene in human lung cancer cells and

Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Virosecurinine, the major alkaloid isolated from Securinega suffruticosa Pall Rehd was found to exhibit growth inhibition and cytotoxicity against huaman colon cancer SW480 cells via the microculture tetrazolium (MTT) assay. Due to its greater cytotoxic potency and selectivity towards SW480 cells,

Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Natural products have been discovered to be valuable sources of antitumor drugs. L-Securinine is a natural product extracted from the leaves or roots of Securinega suffruticosa Pall Rehd. The current study was done to investigate the molecular mechanisms of antitumor effects of L-securinine. The

Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes.

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התחבר הרשם

BACKGROUND During the past few years, there has been an increasing interest among the Traditional and Folk medical practitioners of Sri Lanka in the use of a decoction prepared from Flueggea leucopyrus (Willd.) for treating various cancers including breast cancer. In the present study, the

Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Virosecurinine is a major alkaloid of the plant Securinega suffruticosa and has been found to be a potent agent in inducing the differentiation of cancer cells. The present study aimed to investigate the antitumor effects of virosecurinine by inducing the apoptosis of leukemic K562 cells and to

Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

[structure: see text] Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A (1) and B (2), as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa. Their structures and absolute configurations were elucidated by spectroscopic

Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis.

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התחבר הרשם

Three new Securinega alkaloids, secu'amamines B-D ( 1- 3), were isolated from the wood of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five known analogues ( 4, 6- 9). The structures 1- 3 were elucidated by spectroscopic methods including 2D NMR, and all eight

Three new podocarpane-type diterpenoids from callus of Securinega suffruticosa.

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התחבר הרשם

Three new podocarpane-type diterpenoids, 3beta,12-dihydroxy-13-methyl-6,8,11,13-podocarpatetraen (1), 3beta,12-dihydroxy-13-methyl-5,8,11,13-podocarpatetraen-7-one (2), and 1-(7-hydroxy-2,6-dimethyl-1-naphthyl)-4-methyl-3-pentanone (3)

Fluevirines E and F, two new alkaloids from Flueggea virosa.

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התחבר הרשם

Two new alkaloids, fluevirines E (1) and F (2), along with six known Securinega alkaloids, were isolated from the methanol extract of the twigs and leaves of Flueggea virosa. The structures and absolute configurations of the new compounds were elucidated by means of MS, NMR, and ECD analyses.

Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first

Virosecurinine induces apoptosis in human leukemia THP-1 cells and other underlying molecular mechanisms.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of

Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase.

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התחבר הרשם

Thioredoxin reductase (TrxR) and thioredoxin (Trx) are two major components of the thioredoxin system, which plays essential roles in regulating cellular redox signaling. Mammalian TrxRs are essential seleno-flavoenzymes with a conserved penultimate selenocysteine (Sec) residue at the C-terminus,

Evaluation of antioxidant and antiproliferative activity of Flueggea leucopyrus Willd (katupila).

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Flueggea leucopyrus Willd is a shrub grown in many parts of the dry zones in Sri Lanka. The leaves of F. leucopyrus has been used for treating cancer in the traditional system of medicine in Sri Lanka. Hence, this study was performed to analyze the antioxidant and antiproliferative

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