Subjects would introduce 5 different groups of FODMAPs in a blinded fashion (random order, 1 week on, one week off) while remaining on an otherwise low FODMAP diet while monitoring their IBS symptoms.

Irritable Bowel Syndrome

After 2 weeks on a low FODMAP diet, subject will undergo a reintroduction period. 5 different FODMAPs will be reintroduced (1 week at a time, followed by 1 week washout) in a blinded, randomized fashion.

FODMAP

University of Michigan

Diet Reintroduction Study in Irritable Bowel Syndrome

Charting a Course to a Less Restrictive Diet for IBS

Daily score (0-10) for abdominal pain will be recorded. This will be averaged and compared to the baseline and run-in periods

Daily score (0-10) for bloating will be recorded. This will be averaged and compared to the baseline and run-in periods

Daily stool consistency score will be recorded. This will be averaged and compared to the baseline and run-in periods

Daily number of stools will be recorded. This will be averaged and compared to the baseline and run-in periods

Daily score (0-10) for stool urgency will be recorded. This will be averaged and compared to the baseline and run-in periods

Daily score (0-10) for fatigue will be recorded. This will be averaged and compared to the baseline and run-in periods

Daily score (0-10) for sleep quality will be recorded. This will be averaged and compared to the baseline and run-in periods

Shanti Eswaran

Clinical Assistant Professor

Food items will be blindly reintroduced, and symptoms will be measured.

Participants blinded to randomization of order of reintroduction; Investigators blinded to order of reintroduction

Serial MRI of the gastrointestinal tract upon 500 ml water drink containing 40g glucose

Serial MRI of the gastrointestinal tract upon 500 ml water drink containing 40g fructose

Serial MRI of the gastrointestinal tract upon 500 ml water drink containing 40g fructan

Serial MRI of the gastrointestinal tract upon 500 ml water drink containing 40g fructose and 40 g glucose

Healthy

500 ml water drink containing 40g glucose

Glucose

500 ml water drink containing 40g fructose

Fructose

500 ml water drink containing 40g fructan

Fructan

500 ml water drink containing 40g fructose and 40g glucose

Fructose and glucose

NDDC BRU and Sir Peter Mansfield Magnetic Resonance Centre

Effects of FODMAPs on Small Bowel Water Content: an MRI Study

Effects of FODMAPs (Fermentable Oligo-, Di-, and Mono-saccharides, And Polyols) on Small Bowel Water Content: an MRI Study

Area Under the curve for small bowel water content, methods as Marciani, L., et al., Gastroenterology, 2010. 138(2): p. 469-U90. Hoad, C.L., et al.,. Physics in Medicine and Biology, 2007. 52(23): p. 6909-6922.

AUC of the geometric volume of the ascending colon

motility index of the ascending colon as determined from dynamic MRI scan

bloating, nausea, gas belching and abdominal pain

first time to detect sweetcorn markers in the stool

activity of stool triptase in trypsin units of activity

galactan/עצירות

Diet Reintroduction Study in Irritable Bowel Syndrome

Effects of FODMAPs on Small Bowel Water Content: an MRI Study

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