patient receive their procedure early (within 3 months)

Patient receive their procedure later (in 12 - 15 months), following a year of optimal medical treatment

Chronic Kidney Disease

Obesity

Early bariatric surgery

Delayed bariatric surgery

Nephrology department, CHU de NICE

Bariatric Surgery for Obese Patients With Chronic Renal Insufficiency

The change in mGFR is calculated as the difference between mGFR at M12 and mGFR at M0. These differences will be compared between the groups using covariance analysis adjusted on initial mGFR values (M0). Additional adjustment will include variables described in the analysis strategy.

Centre Hospitalier Universitaire de Nice

The experimental arm of this study will involve all patients in this study. Subjects will be evaluated in a clinical setting and undergo a brief healthcare questionnaire, blood work, and a breath test. Subjects will then take a medical food (EnteraGam) twice daily for 8 weeks total, after which they will be seen in clinic at 4 weeks for follow up and then at 8 weeks to repeat the healthcare questionnaire, breath tests, and blood draw.

Cirrhosis of the Liver

Ascites

Spontaneous Bacterial Peritonitis

Visit 1, screening (Day 0): At this visit, the investigators of the study will:
Obtain demographic information, as will past medical history and medications.
Perform a physical examination.
Collect samples for labs
Administer the Chronic Liver Disease Questionnaire (CLDQ)
Perform a lactulose breath test
From Day 0 to 8 weeks: subjects will take the medical food twice daily
Visit 2, Week 4 (Day 28 +/- 3): At this visit, the investigators of the study will:
Perform a physical examination
Collect and record returned investigational product
Dispense investigational product and instruct again regarding use
Record any adverse events
Visit 3, Week 8 (Day 56 +/- 3): At this visit, the investigators of the study will:
Perform a physical examination.
Collect samples for labs
Administer the Chronic Liver Disease Questionnaire (CLDQ)
Perform a lactulose breath test

Medical food, EnteraGam (Serum-Derived Bovine Immunoglobulin)

Saint Louis University Salus Center, GI/Hepatology Clinical Studies Unit

Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Decompensated Cirrhosis With Ascites

LBP (Lipopolysaccharide binding protein)
Soluble CD14
Procalcitonin
high sensitivity C-Reactive Protein (CRP)
Intestinal Fatty Acid Binding Protein (I-FABP)

Hydrogen breath test (using lactulose as the substrate)

Quality of life will be determined with the use of the Chronic Liver Disease Questionnaire (CLDQ), a validated questionnaire used in subjects with cirrhosis. The CLDQ includes 29 questions in six domains: abdominal symptoms (three questions), fatigue (five questions), systemic symptoms (five questions), activity (three questions), emotional function (eight questions), and worry (five questions).

inulin/בצקת

Bariatric Surgery for Obese Patients With Chronic Renal Insufficiency

Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Decompensated Cirrhosis With Ascites

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע