90Y-DOTA-TOC will be administered one time over thirty minutes via the hepatic arterial catheter in the outpatient setting. The injected dose will be 85 to 115 mCi.

90Y-DOTA-TOC will be administered one time over thirty minutes via the hepatic arterial catheter in the outpatient setting. The injected dose will be 85 to 115 mCi.
Patients enrolled in the correlative sub-study will also receive 111-259 MBq (3-7 mCi) of 68Ga-DOTA-TOC concurrent with 90Y-DOTA-TOC

Neuroendocrine Tumor

Starting 30 minutes prior to the administration of 90Y-DOTA-TOC, amino acid solution will be administered via IV, and will continue through the PRRT procedure. An angiographic catheter will be inserted under fluoroscopic guidance to the appropriate location in the hepatic artery. 90Y-DOTA-TOC will be administered via the hepatic arterial catheter.

90Y-DOTA-TOC

In the sub-study, 10 patients will receive 68Ga-DOTA-TOC concurrent with the 90Y-DOTA-TOC dose and 90 minutes after treatment, these patients will be imaged using a PET/CT. The following day, patients enrolled in the sub-study will undergo a PET/MRI.

68Ga-DOTA-TOC

University of California, San Francisco

Yttrium-90 DOTA-TOC Intra-arterial (IA) Peptide Receptor Radionuclide Therapy (PRRT) for Neuroendocrine Tumor

Based on change in size of hepatic lesions three and six months after treatment with IA 90Y-DOTA-TOC using RECIST criteria.

Based on laboratory evaluation and CTCAE 4.0 criteria.

Data from patients in the imaging correlate sub-study only

Thomas Hope

Assistant Professor

Main study: All participants will receive a single administration of intra-arterial 90Y-DOTA-TOC.
There will be a sub-study involving 10 patients from the main study who will undergo additionally correlative imaging to compare IA vs IV administration (intra-arterial 68Ga-DOTA-TOC administration and subsequent PET imaging).

First to use standard white light to observe, to record spasm score, to observe the lesion.Buscopan (BSP, 20mg) is administered by endoscopic nurse, recorded blindly.

First to use standard white light to observe, to record spasm score, to observe the lesion.Scopolamine is administered by endoscopic nurse, recorded blindly.

First to use standard white light to observe, to record spasm score, to observe the lesion. Physiological saline is administered by endoscopic nurse, recorded blindly.

Gastrointestinal Imaging With pCLE

Buscopan is administered by endoscopic nurse in the Buscopan group,and then recording the outcome measures.

Buscopan

Scopolamine is administered by endoscopic nurse in the Scopolamine group,and then recording the outcome measures.

Scopolamine

Physiological saline is administered by endoscopic nurse in the physiological saline group,and then recording the outcome measures.

physiological saline

Xijing Hospital of Digestive Diseases

Effect of Buscopan on Gastrointestinal Imaging Quality With Probe-based Confocal Laser Endomicroscopy

the rate which spasm score decline was significant (spasm score decline two points before and after the drug)

the rate of participants among which the pCLE diagnosis agree with the pathologic diagnosis

Shuhui Liang

Associated Professor

Ulcerative Colitis

conventional white light colonoscopy

FICE (Fujinon Intelligent Chromoendoscopy)

Departement d'Endoscopie digestive - Hopital Archet 2, CHU de Nice

Comparison Between Chromoendoscopy and Conventional Colonoscopy to Improve the Detection of Neoplasia in Patients With Ulcerative Colitis (UC)

Comparaison de la Chromo Endoscopie Virtuelle FICE (Fujinon Intelligent Chromoendoscopy) Avec la Coloscopie Conventionnelle Dans la détection de la Dysplasie Chez Patients Porteurs de Recto Colite ulcéro hémorragique (RCH).

neoplasms/scopolamine

Yttrium-90 DOTA-TOC Intra-arterial (IA) Peptide Receptor Radionuclide Therapy (PRRT) for Neuroendocrine Tumor

Effect of Buscopan on Gastrointestinal Imaging Quality With Probe-based Confocal Laser Endomicroscopy

Comparison Between Chromoendoscopy and Conventional Colonoscopy to Improve the Detection of Neoplasia in Patients With Ulcerative Colitis (UC)

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע