noradrenaline/סרטן

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[Effect of intraarterial noradrenaline-induced hypertensive chemotherapy of hepatic metastasis in gastric cancer].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Four patients with hepatic metastasis of gastric cancer (one synchronous, three metachronous), received intraarterial noradrenaline-induced hypertensive chemotherapy. The outlet of the indwelling catheter was placed in the proper hepatic artery in two patients, in the thoracic aorta in one patient

[Effects and problems of intraarterial noradrenaline-induced hypertensive chemotherapy for liver metastasis of gastric cancer].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Intraarterial noradrenaline-induced hypertensive chemotherapy (NA-IHC) was performed on eight patients with liver metastasis of gastric cancer (3 synchronous and 5 metachronous). Mitomycin C was injected via the indwelling catheter placed in the proper hepatic artery, when the mean systolic blood

As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The CREM (cAMP-response-element modulator) gene product ICER (induced cAMP early repressor) has been proposed to function as a tumour (cell proliferation) suppressor. To investigate the generality of this concept, the expression pattern of ICER in brown adipocytes was followed; this was critical

Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastases.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Vasopressors administered via the hepatic artery appear to increase drug delivery to colorectal liver metastases, but are limited by a short duration of action. This study measured their effect on blood flow and drug delivery during a prolonged infusion in a model of liver

Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Noradrenaline induced changes in the distribution of blood flow in implanted tumour and normal liver tissue was measured using blood flow tracer microspheres. The ratio of embolised microspheres in tumour compared to normal tissue was determined before and after the intravenous infusion of

[131I]meta-iodobenzylguanidine and topotecan combination treatment of tumors expressing the noradrenaline transporter.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

OBJECTIVE Both [(131)I]meta-iodobenzylguanidine ([(131)I]MIBG) and the topoisomerase I inhibitor topotecan are effective as single-agent treatments of neuroblastoma. The aim of this study was to investigate the efficacy of [(131)I]MIBG in combination with topotecan in vitro and in vivo. METHODS The

Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen species.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma. Enhancement of 131I-MIBG's efficacy is achieved by combination with the topoisomerase I inhibitor topotecan - currently being

Protective effects of noradrenaline on benzo[a]pyrene-induced oxidative stress responses in brain tumor cell lines.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Benzo[a]pyrene (B[a]P) is an ubiquitous environmental pollutant that is generated during combustion of fossil fuels. We examine the effect of noradrenaline (NA) on B[a]P-induced neurotoxicity in brain tumor cell lines like neuroblastoma (Neuro2a) and glioma (C6). We pre-treated tumor cells with NA

[Microvascular injury in hyperthermia by injecting warm water using noradrenaline into tumor feeding artery-induced tumor necrosis of Walker-256].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Wistar rats were injected sc, with cells from Walker-256, which is resistant to hyperthermia. When hyperthermia was achieved by immersing the tumor at 44 degrees C for 60 minutes after injecting MMC (0.5 mg/kg), tumor growth was markedly suppressed in D-8 group, which formed many tumor vessels, but

Cardiac output redistribution induced by noradrenaline in two murine tumor models.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The response of tumor vessels to vasoactive substances could provide useful information on experimental tumor biology. We have studied the effects of noradrenaline (20 micrograms/kg i.v.) on cardiac output (%CO) distribution in C57BL/6J mice bearing syngeneic Lewis lung carcinoma (3LL) and BALB/c

Duloxetine improves cancer-associated pain in a mouse model of pancreatic cancer via stimulation of noradrenaline pathway and its antitumor effects

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. Patients with inoperative PDAC require effective chemotherapy and pain control to increase their quality of life. We investigated whether duloxetine, a serotonin-noradrenaline reuptake inhibitor, improves quality

[Enhancement of anti-cancer effect by increased injection pressure of a single shot in intra-arterial chemotherapy--the advantage of using noradrenaline in intra-arterial chemotherapy. An experimental study].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

In vivo evaluation of a cancer therapy strategy combining HSV1716-mediated oncolysis with gene transfer and targeted radiotherapy.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Oncolytic herpes viruses show promise for cancer treatment. However, it is unlikely that they will fulfill their therapeutic potential when used as monotherapies. An alternative strategy is to use these viruses not only as oncolytic agents but also as a delivery mechanism of therapeutic transgenes

Quercetin-3-O-glucronide inhibits noradrenaline binding to α2-adrenergic receptor, thus suppressing DNA damage induced by treatment with 4-hydroxyestradiol and noradrenaline in MCF-10A cells.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Risk factors for breast cancer include estrogens such as 17β-estradiol (E2) and high stress levels. 4-Hydroxyestradiol (4-OHE2), a metabolite of E2 formed preferentially by cytochrome P450 1B1, is oxidized to E2-3,4-quinone, which reacts with DNA to form depurinating adducts that exert genotoxicity

Managing Menopausal Symptoms and Associated Clinical Issues in Breast Cancer Survivors.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Review evidence to guide management of menopausal signs and symptoms in women after breast cancer and make recommendations accordingly. Randomized controlled clinical trials, observational studies, evidence-based guidelines, and expert opinion from professional societies. Symptoms and clinical

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