The enrolled subjects will then be randomized into two groups. Study Group: will take a supplementation pill containing 5 g L-arginine (0.5g/ pill, GNC, USA) All the food intake of the subjects during the 4 weeks of the study will be recorded and supervised by responsible dietitians.

The enrolled subjects will then be randomized into two groups. Control group: will take a supplementation pill containing 5 g whey protein (5g/ pack, Santosa,Taiwan).
All the food intake of the subjects during the 4 weeks of the study will be recorded and supervised by responsible dietitians.

Diabetes Mellitus, Type 2

Infection

The enrolled subjects will then be randomized into two groups. The subjects will receive either L-arginine (the study group) or another amino acid supplement (the control group), with 60 patients in each group. All the food intake of the subjects during the 4 weeks of the study will be recorded and supervised by responsible dietitians.

L-arginine supplements and nutritional supports

Chang Gung Memorial Hospital

Metabolomics and Wound Healing in Diabetes

Metabolomics and Wound Healing in Diabetes―Mechanisms and Clinical Value of Arginine Supplement in Patients With Diabetic Foot Ulcers

Wound assessment was recorded using the PEDIS system

Ministry of Science and Technology, Taiwan

Subjects in this group will be asked to consume the nutritional supplement on a daily basis, in addition to standard nutrition. Subjects will have pain medication and postoperative therapies per standard of care.

Subjects in this group will have standard nutrition provided per dietitian recommendation. Subjects will have pain medication and postoperative therapies per standard of care.

Trauma

Nutritional Deficiency

Wound Heal

Nutritional supplement (Juven) will be consumed daily per manufacturer recommendations

Juven

University of Iowa Hospitals and Clinics

Trauma Screening and Supplementation

Improving Preoperative Screening and Postoperative Nutrition in Trauma Patients: Does it Decrease Muscle Wasting or Complications

Change in hand grip strength as measured by hand held dynamometer

Medical and surgical complications following operative fracture fixation, validated patient reported outcome measures, radiographic measures of fracture healing, time spent in hospital, discharge status (home versus acute rehabilitation versus skilled nursing facility)

Nathan Hendrickson

Principal Investigator

Orthopaedic Trauma Association

Subjects will receive 8 weeks of daily pioglitazone (30mg/day).

Subjects will receive 8 weeks of daily placebo capsules.

Spinal Cord Injury

Pressure Ulcers

Pioglitazone

Placebo

James J. Peters VA Medical Center

Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI

Insulin Sensitivity in the Peri-Wound Microcirculation of Pressure Ulcers in SCI

To determine the perfusion response to insulin administered by iontophoresis to the cutaneous peri-wound region of a chronic pelvic region pressure ulcer before and after treatment with pioglitazone (30 mg/d x 8 weeks).

To determine the association between the therapeutic effects of pioglitazone on the homeostatic model assessment of insulin resistance (HOMA-IR) and cutaneous peri-wound perfusion response to transdermal insulin administration.

To determine the reliability of laser speckle contrast analysis imaging to detect meaningful interventional change in cutaneous peri-wound perfusion to pioglitazone treatment.

pressure ulcer/carbohydrate

Metabolomics and Wound Healing in Diabetes

Trauma Screening and Supplementation

Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע