עמוד 1 מ 42 תוצאות
FIELD OF THE INVENTION
Treatments for estrogen receptor and progesterone receptor negative breast cancer or estrogen receptor, progesterone receptor and c-erbB2 negative (triple negative) breast cancer are provided.
BACKGROUND OF THE INVENTION
Cancer/testis (CT) antigens constitute a unique group of
FIELD OF THE INVENTION
The present invention relates to compositions and methods for treating an estrogen-dependent condition. More specifically, the present invention relates to compositions comprising one or more progesterone antagonists for suppressing endometrial proliferation.
BACKGROUND OF THE
FIELD OF THE INVENTION
The present invention relates to compositions and methods for treating an estrogen-dependent condition. More specifically, the present invention relates to compositions comprising one or more progesterone antagonists for suppressing endometrial proliferation.
BACKGROUND OF THE
BACKGROUND OF THE INVENTION
Progesterone is a naturally occurring steroid which is the main steroid secreted by women during their reproductive years. This steroid has been studied extensively and has been found to be a major precursor in the biosynthesis of most other steroids, particularly
FIELD OF THE INVENTION
This invention generally relates to expression profiles of genes that are regulated by progesterone receptors, and particularly by progesterone receptor isoforms PR-A and PR-B, and to the use of such genes in methods for identifying progesterone receptor agonist and antagonist
The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for the production of medicinal products
FIELD OF THE INVENTION
The present invention relates to the field of antibodies. In particular the present invention discloses an antibody ideal for immunohistochemical staining without difficult target retrieval procedures.
BACKGROUND OF THE INVENTION
A standard technique for medical diagnosis is
FIELD OF THE INVENTION
The invention provides a method for treatment of primary progesterone receptor-negative (PR-) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (PR) agonist. The invention further provides a method for
INCORPORATION OF SEQUENCE LISTING
Incorporated herein in its entirety and submitted herewith is the computer readable Sequence Listing. The Sequence Listing is disclosed on a computer-readable ASCII text file titled "SequenceListing294-411CON.txt", date modified on Oct. 28, 2015. The sequence.txt
INCORPORATION OF SEQUENCE LISTING
Incorporated herein in its entirety and submitted herewith is the computer readable Sequence Listing for the above-identified Application. The Sequence Listing is disclosed on a computer-readable ASCII text file titled "SequenceListing294-411.txt", date modified on
FIELD OF THE INVENTION
The present invention relates to prognosis of breast cancer metastasis. In particular, the present invention relates to a multi-gene prognostic signature typically comprising 14 genes (which may be referred to herein as a "metastasis score" ("MS")) in combination with
BACKGROUND OF THE INVENTION
Estrogen receptor .alpha. (ER.alpha.) is a member of the steroid/nuclear receptor family of transcription regulators and mediates cell growth and metastases, and resistance to apoptosis and immunosurveillance (see references 1-5). ER.alpha. is activated by binding of
FIELD OF THE INVENTION
Particular aspects relate generally to DNA methylation and hormone receptor biology, and particularly to prognostic and diagnostic methods relating to cancer (e.g., breast cancer), and to methylation marker-based methods for predicting response to endocrine (e.g.,
FIELD OF THE INVENTION
The present invention is in the field of biotechnology and specifically relates to the field of breast cancer screening in women.
BACKGROUND TO THE PRESENT INVENTION--THE RELATED ART
For well over twenty years, thermometric assessment of the human female breast surface has
BACKGROUND
(a) Field
The present invention relates to a method for prognosing or predicting overall survival (OS) or metastasis in a subject with triple negative (TN) breast cancer. More specifically, the invention relates to two sets of biomarkers, one set useful for prognosing or predicting OS in