proline/השמנת יתר חולנית

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Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet.

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התחבר הרשם

BACKGROUND Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage in

The role for cyclic Glycine-Proline, a biological regulator of insulin-like growth factor-1 in pregnancy-related obesity and weight changes.

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התחבר הרשם

Cyclic Glycine-Proline (cGP) regulates the homeostasis of insulin-like growth factor (IGF)-1 function and cGP/IGF-1 ratio determines IGF-1 bioactivity in vitro and in vivo. Plasma IGF-1 represents largely inactive IGF-1 and weakly associated with human obesity and hypertension. We evaluated the

Cyclic glycine-proline administration normalizes high-fat diet-induced synaptophysin expression in obese rats.

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התחבר הרשם

Childhood metabolic disorders are associated with insulin-like growth factor (IGF)-1 deficiency, which can adversely affect brain development and function. As a neuropeptide, cyclic glycine-proline (cGP) improves IGF-1 function in brain and regulates IGF-1 bioavailability in plasma. Whether such a

Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats.

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התחבר הרשם

Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glycine-proline (cGP) is a natural nutrient and regulates the amount of active IGF-1 in plasma. Plasma cGP decreases in hypertensive women whereas increases in obese women,

Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.

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התחבר הרשם

Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor. After medicinal chemistry optimization and SAR studies, orally active proline amides with robust efficacy in a rodent food intake inhibition model were uncovered.

Endogenous histidyl-proline diketopiperazine [cyclo (His-Pro)]: a potential satiety neuropeptide in normal and genetically obese rodents.

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התחבר הרשם

Hepatic collagen proline hydroxylase activity in hepatic disease following jejunoileal bypass for morbid obesity.

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התחבר הרשם

Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function.

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התחבר הרשם

Apolipoprotein (apo)A-IV is a lipid emulsifying protein linked to a range of protective roles in obesity, diabetes, and cardiovascular disease. It exists in several states in plasma including lipid-bound in HDL and chylomicrons and as monomeric and dimeric lipid-free/poor forms. Our recent x-ray

Higher intakes of energy-adjusted dietary amino acids are inversely associated with obesity risk.

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התחבר הרשם

We assessed the relationship between energy-adjusted amino acids (EAA) intakes and obesity risk using data on nutrient intakes derived from the Chinese food composition tables to determine dietary intakes (DI) among 1109 obese and 3009 normal weight subjects. Dietary patterns (DP) were identified

Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.

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התחבר הרשם

Leucine 7 (Leu7) to proline 7 (Pro7) substitution in the neuropeptide Y (NPY) gene has been associated with higher serum total and low-density lipoprotein (LDL) cholesterol levels, particularly in obese subjects. We investigated the frequency of the Pro7 allele and the association of the

Biomarker Identification of Maternal Genistein Exposure Induced Obesity by Metabonomics Analysis.

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התחבר הרשם

The objective of this study was to confirm the effect of maternal genistein exposure on body weight of male offspring and the metabolic alterations associated with maternal genistein-induced obesity. Pregnant female Sprague-Dawley (SD) rats were supplemented with 300 mg/kg diet of genistein (GEN) or

Association of hyperprolinaemia type I and heparin cofactor II deficiency with CATCH 22 syndrome: evidence for a contiguous gene syndrome locating the proline oxidase gene.

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התחבר הרשם

Increased proline levels were found in plasma of a girl with slight psychomotor retardation, epilepsy, obesity, scoliosis, hypocalcaemia, variable lymphocytopenia and facial dysmorphy suggestive of CATCH 22 syndrome. Fluorescence in situ hybridization indicated the presence of a submicroscopic 22q11

Intestinal nutrient transport in genetically obese mice.

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התחבר הרשם

The small intestine of obese animals supplies nutrients to a metabolic live mass (body weight 0.75) that is much higher than that of age- and sex-matched lean animals. To determine the mechanisms of adaptation of the small intestine to obesity, we determined the rate of uptake of D-glucose and five

Peptidase activities in the functioning jejunum and ileum before and after jejunoileal bypass in morbid obesity.

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התחבר הרשם

Different peptidase activities were studied preoperatively and postoperatively on intestinal biopsy specimens from patients with jejunoileal bypass for morbid obesity. Preoperatively the activities of the brush border peptidases, microvillus aminopeptidase (EC 3.4.11.2) and dipeptidyl peptidase IV

A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia.

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התחבר הרשם

BACKGROUND Peroxisome proliferators-activated receptor gamma (PPAR gamma) is a nuclear hormone receptor that serves as a master regulator of adipocytes-specific genes contributing to adipocytes differentiation, susceptibility to obesity, and insulin sensitivity. The substitution of proline to

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