The genetically modified hemorrhagic fever virus of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent.

Colorado Seminary, which owns and Operates The University of Denver

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Colorado Seminary, which owns and operates the University of Denver

Crimean-Congo hemorrhagic fever virus vaccine

The genetically modified nairoviruses of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Exemplary are Crimean-Congo hemorrhagic fever virus and Erve virus. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent for prophylaxis and treatment.

The United States of America as Represented by the Secretary of the Department of Health and Human Services

COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Attenuated live vaccine for Crimean-Congo hemorrhagic fever virus and Erve virus

protease

חום

fever

protease/חום

Crimean-Congo hemorrhagic fever virus vaccine

Attenuated live vaccine for Crimean-Congo hemorrhagic fever virus and Erve virus

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע