The invention provides a method for regulating neuronal degeneration resulting from injury to nervous tissue. The method includes regulating the expression or activity of protease, preferably tissue-type plasminogen activator (tPA), by microglial cells. Alternatively, the method involves regulating microglial activation in response to injurious conditions. The method, in an alternative embodiment, includes detecting tPA expression or activity, or detecting microglial activation. In addition, the method includes assessing the susceptibility of a human or animal subject to seizure, and may involve detecting the activity or expression of tPA, and may further involve comparing a measured level of tPA expression or activity with a reference level associated with a given probability of seizure.

The Research Foundation of State University of New York

Method for reducing neuronal degeneration associated with seizure

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a ubiquitin-specific protease 16 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

protease/פרכוס אפילפטי

Method for reducing neuronal degeneration associated with seizure

Transgenic mice exhibiting increased susceptibility to seizures

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע