retinoic acid/חום

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All trans retinoic acid sensitizes colon cancer cells to hyperthermia cytotoxic effects.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The effects of all trans retinoic acid and hyperthermia were studied in the human colon adenocarcinoma cell line HT29. Cell cytotoxicity after exposure to ATRA or heat-shock, alone or in association, was evaluated by the MTT assay while cell surface and ultrastructure modifications and actin fibre

Synergistic cell killing by combination therapy of retinoic acid and hyperthermia in human epidermoid laryngeal carcinoma cells in culture.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

In vitro monolayer culture and clonogenic assay were used to investigate the individual and combined effect of temperature and retinoic acid (RA) on cellular morphology and colony forming ability of human epidermoid laryngeal carcinoma (HEp-2) cells. 20 micromol. RA alone inhibited multilayer

Radiofrequency hyperthermia and topical retinoic acid therapy in murine melanoma.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Malignant cells are known to be sensitive to increased temperature. The effects of hyperthermia (HT) on intradermally implanted S91 melanoma cells in syngeneic mice were investigated with a hand-held radiofrequency generator. The possible additive effects of topical retinoic acid (RA) in this system

[High fever during the treatment of acute promyelocytic leukemia with all-trans retinoic acid].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

A 56-year-old woman was admitted for evaluation of petechiae and acute promyelocytic leukemia was diagnosed. Administration of all-trans retinoic acid (ATRA) at 60 mg per day was begun. On the same day, high fever was recognized. There was no evidence of infection nor other organ dysfunction.

Increase in carcinoembryonic antigen release from cancer cells by combined treatment with retinoic acid and low-temperature hyperthermia.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The growth of a human gastric adenocarcinoma cell line, MKN-45, was inhibited and the amount of carcinoembryonic antigen (CEA) in both the culture medium and the cell extract was increased in the presence of retinoic acid at a concentration of 75 (1.5x)-125 microM (1.9x), which did not substantially

Phase 1B study of subcutaneously administered interleukin 2 in combination with 13-cis retinoic acid as maintenance therapy in advanced cancer.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

At present, no therapeutic strategy is available to maintain responses achieved in patients treated with chemotherapy. This Phase IB study was aimed at identifying the optimal biological dose of chronic maintenance therapy using s.c. interleukin (IL) 2 and oral 13-cis retinoic acid (RA) in patients

All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Blood vitamin A profiles, including concentrations of retinol and its active metabolite retinoic acid, were assessed during the peripartum period and during experimentally induced Escherichia coli mastitis in heifers. Serum retinol decreased in all animals in the immediate postpartum period and

Retinoic acid syndrome: manifestations, pathogenesis, and treatment.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

All-trans retinoic acid (ATRA) is a potent differentiation agent that is effective therapy in acute promyelocytic leukaemia. Although ATRA is generally well tolerated, some patients develop retinoic acid syndrome. This syndrome is manifested by unexplained fever, weight gain, respiratory distress,

Retinoic acid syndrome: a case report.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

All-trans-retinoic acid (ATRA) is a differentiation agent which can induce complete remission in a majority of patients with acute promyelocytic leukemia (APL). Unfortunately, about one-fourth of patients thus treated may develop potentially fatal complications, including respiratory distress,

Acute renal failure associated with the retinoic acid syndrome in acute promyelocytic leukemia.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

All-trans-retinoic acid is an effective agent to induce remission in patients with acute promyelocytic leukemia (APL). Unlike conventional chemotherapy, this drug exerts its effect by inducing differentiation of immature leukemic cells. A distinctive clinical syndrome characterized by fever,

Retinoic acid syndrome induced by arsenic trioxide in treating recurrent all-trans retinoic acid resistant acute promyelocytic leukemia.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Arsenic Trioxide (As2O3) is an effective agent for treating acute promyelocytic leukemia achieving a complete remission rate of about 60% to 90%. It is similar to all-trans retinoic acid (ATRA) when treating acute promyelocytic leukemia (APL), because both agents have limited side effects compared

All-trans-retinoic acid-induced myositis: a description of two patients.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

All-trans-retinoic acid (ATRA) induces complete clinical remissions in a high proportion of patients with acute promyelocytic leukemia and has become the standard induction therapy. Its use as a single agent results in short-lived remissions; thus, cytotoxic drugs are used for "consolidation"

[A "retinoic acid syndrome" observed in two cases of acute promyelocytic leukemia].

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Two cases of acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) developed fever, dyspnea and chest pain. A chest roentgenogram showed bilateral pleural effusion (case 1) and bilateral interstitial infiltration (case 2). The first case was a 50-year-old female in her first

Gangrenous cheilitis associated with all-trans retinoic acid therapy for acute promyelocytic leukemia.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

A 67-year-old Japanese woman who presented with erythema on the abdomen and pancytopenia was found to have acute promyelocytic leukemia (APL). A skin biopsy revealed invasion of APL cells. She was started on induction treatment with all-trans retinoic acid (ATRA) at 45 mg/m(2). On day 4, the

Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. METHODS We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and

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