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retinoic acid/סרטן

הקישור נשמר בלוח
עמוד 1 מ 2405 תוצאות
The chemotherapeutic agent retinoic acid (RA) inhibits the proliferation and invasion of many tumor types. RA chemotherapy in head and neck squamous cell carcinoma (SCC) patients reduces recurrence and induces regression of premalignant lesions. The effects of RA are mediated by both cytoplasmic and

Phase 1B study of subcutaneously administered interleukin 2 in combination with 13-cis retinoic acid as maintenance therapy in advanced cancer.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
At present, no therapeutic strategy is available to maintain responses achieved in patients treated with chemotherapy. This Phase IB study was aimed at identifying the optimal biological dose of chronic maintenance therapy using s.c. interleukin (IL) 2 and oral 13-cis retinoic acid (RA) in patients

Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Neuroblastoma is the most common extracranial solid tumor in childhood. The different treatments available for neuroblastoma are challenged by high rates of resistance, recurrence, and progression, most notably in advanced cases and highly malignant tumors. Therefore, the development of more
BACKGROUND Retinoids exert anti-proliferative, differentiative, and apoptosis-inducing effects through their receptors. Retinoic acid receptor (RAR) β2 behaves as a tumor suppressor gene, and its expression is suppressible by DNA methylation in many malignancies. OBJECTIVE We aimed to determine

Synthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
With the purpose of creating a multifunctional drug for gastric cancer treatment, a novel all-trans-retinoic acid (ATRA) conjugate with podophyllotoxin (PPT) was designed and synthesized, and its in vitro antiproliferative activity was evaluated against human gastric cancer cell lines using CCK-8

Human lung cancer cell lines exhibit resistance to retinoic acid treatment.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Retinoic acid (RA) and nuclear retinoic acid receptors (RARs) have been implicated in a variety of human malignancies including lung cancer, and RA has been proposed as a chemopreventive agent for bronchogenic carcinoma. Normal human tracheobronchial epithelial cells show dramatic induction of

All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
The relapse of cancer is mostly due to the proliferation of cancer stem cells which could not be eliminated by a standard chemotherapy. A new kind of all-trans retinoic acid stealth liposomes was developed for preventing the relapse of breast cancer and for treating the cancer in combination with a

13-cis-retinoic acid and cancer chemoprevention.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Chemoprevention is the newest strategy for controlling and managing cancer. At present, the multistep character of epithelial carcinogenesis makes this disease process the most amendable to chemopreventive interventions, which occur in the postinitiation, preinvasive phases. Chemoprevention study
Retinoic acid (all-trans and 9-cis) isomers represent important therapeutic agents for many types of cancers, including human breast cancer. Changes in protein composition of the MCF-7 human breast cancer cells were induced by all-trans retinoic acid, 9-cis retinoic acid, and their combination and

Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Liarozole fumarate (R85,246), a novel benzimidazole derivative, reduced s.c. and bone metastasis tumor growth by the androgen-independent PC-3ML-B2 human prostatic carcinoma clone in SCID mice. The drug inhibited cell invasion of Matrigel in Boyden chamber chemotactic assays and the secretion of

Retinoic acid and interferon combination studies in human cancer.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Retinoic acid and interferon-alpha have limited single-agent activity in advanced cancer. Cell culture data indicate that in combination these agents have enhanced activity (modulating growth and differentiation) in a number of malignant cell types. Recent clinical work in advanced squamous cell
Retinoids are well known as potential chemopreventive and chemotherapeutic agents against a variety of human cancers. Here, we report that retinoic acid (RA) induced differential growth inhibition in human colon cancer cell lines: while DLD-1, HT-29, and WiDr were relatively resistant, HCT-15 and

Molecular determinants of retinoic acid sensitivity in pancreatic cancer.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
OBJECTIVE To identify a predictive molecular "signature" for sensitivity to retinoic acid in pancreatic cancer. METHODS Fourteen patient-derived, low-passage pancreatic ductal adenocarcinoma (PDAC) lines with varied expression of fatty acid-binding protein 5 (FABP5) and cellular retinoic

[All-trans retinoic acid (ATRA) in prevention and cancer therapy].

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Retinoids are useful pharmacological agents in therapy and prevention of cancer. All-trans retinoic acid (ATRA) is applied in chemoprevention and differentiation therapy of some cancers with particularly impressive results in the management of acute promyelocytic leukemia (APL). ATRA plays a major

Inhibition of 7-bromomethylbenz[a]anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone.

רק משתמשים רשומים יכולים לתרגם מאמרים
התחבר הרשם
Retinoic acid, a potent inhibitor of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate, fails to inhibit tumor formation by the complete carcinogen, 7, 12-dimethylbenz[a]anthracene (DMBA). To obtain further clues about the nature of the mechanism of the carcinogenic process as well
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