Placebo-controlled Trial to Assess the Efficacy and Safety of Subcutaneous Histamine Dihydrochloride for Migraine Prophylaxis.

Migraine Prophylaxis

Histamine Dihydrochloride

Subcutaneous placebo (Evan's solution = phenol 0.4%, isotonic sodium chloride).

A Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Subcutaneous Histamine Dihydrochloride for Migraine Prophylaxis

Phase II Study to Assess the Efficacy and Safety of Subcutaneous Histamine Dihydrochloride for Migraine Prophylaxis

Mean change from baseline in monthly migraine days [time frame: baseline and average over Weeks 3-22].

Mean change from baseline in monthly migraine days by 4 week intervals [Weeks 3-6, 7-10, 11-14, 15-18, 19-22].

Mean Change from Baseline in Monthly Migraine Index (MMI) [ Time Frame: baseline and average over observation period (Weeks 3-22).
Monthly Migraine Index (MMI):
Migraine headaches are assigned a number based on the peak intensity of that migraine headache:
1 for a mild migraine headache
2 for a moderate migraine headache
3 for a severe migraine headache.
The MMI is calculated as follows:
MMI= Sum of [(Migraine Peak Intensity Level (1-3)) x (Migraine Duration (hours))] / (Distinct Number of Migraine Headaches for that 4 week period)
Sample Calculation:
The patient experiences 3 migraine headaches (M1, M2, and M3) in 4 weeks . M1: Intensity Level 3, Duration is 7 hrs M2: Intensity Level 2, Duration 3 hrs M3: Intensity Level 3, Duration 15 hrs MMI= (3x7 + 2x3 + 3x15) / 3 = 24

Mean change from baseline in monthly number of migraines [time frame: baseline and over Weeks 3-22].

Mean change from baseline in monthly number of migraines by 4 week intervals [Weeks 3-6, 7-10, 11-14, 15-18, 19-22].

AgoneX Biopharmaceuticals, Inc.

Modified ORS -1 will be assigned to the enrolled particfipants according to the randomization schedule.

Modified ORS -2 (ReSoMal) will be assigned to the enrolled particfipants according to the randomization schedule.

Modified ORS -3 (Benefibre) will be assigned to the enrolled particfipants according to the randomization schedule.

Malnourished Children With Watery Diarrhoea

Modified ORS-1

Modified ORS-2 (ReSoMal)

Modified ORS-3 (Benefibre)

Dhaka Hospital, icddr,b

Modified ORS Solution for Severely Malnourished Children

Optimisation of Oral Rehydration Solution and Evaluation of the Efficacy of Benefiber(Partially Hydrolyzed Guar Gum) Containing Modified Oral Rehydration Solution in the Treatment of Severely Malnourished Children With Watery Diarrhoea

Collection of stool in cholera cot and measured every 6 hours with a using a electronic scale

Time from the onset of randomization upto the stopage of diarrhoea

riboflavin/הקאה

A Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Subcutaneous Histamine Dihydrochloride for Migraine Prophylaxis

Modified ORS Solution for Severely Malnourished Children

Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children.

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע