taxus brevifolia/אנטי פטרייתי

הקישור נשמר בלוח

מאמריםניסויים קלינייםפטנטים

בחר סוג מיון

15 תוצאות

In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Taxol is an effective antineoplastic agent, originally extracted from the bark of Taxus brevifolia with a low yield. Many attempts have been made to produce Taxol by chemical synthesis, semi-synthesis and plant tissue cultures. However, to date, the availability of this compound is not

Isolation of two highly methylated polyketide derivatives from a yew-associated penicillium species

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structures of these highly methylated polyketide derivatives were deduced by detailed analysis of both 1D and 2D NMR and difference NOE spectra. Both

The effect of paclitaxel on the radiosensitivity of gynecological tumor cells.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Paclitaxel, a natural product from Taxus brevifolia, is a microtubule stabilizing agent, which has been shown to block different cells in the G2/M phase of the cell cycle and consequently, to modulate their radioresponsiveness. Our aim was to test the cytotoxic and radiosensitizing

The pharmacology of extinction.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

It is impossible to predict what compounds of pharmacological interest may be present in an unexamined species. The extinction of such species may result, therefore, in the loss of therapeutically significant compounds. The fact that science will never know what has been lost does not lessen the

High sensitivity ELISA determination of taxol in various human biological fluids.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Taxol (paclitaxel)--the natural product isolated from Pacific yew (Taxus brevifolia)--is a novel agent with high activity in the treatment of patients with several malignant tumors including those resistant to other cytotoxic drugs. The therapeutic index of this promising anticancer drug could be

Design, synthesis and biological activity of protaxols.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Taxol is a product isolated from the Pacific yew tree (Taxus brevifolia) and is a potent microtubule-stabilizing agent which has recently been approved for treatment of otherwise intractable ovarian cancer. Despite taxol's therapeutic promise, its aqueous insolubility (< 0.004 mg ml-1) hampers its

Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds of particular interest is the microtubule-stabilizing agents, the most well-known compound of this group being paclitaxel (Taxol), an

Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND Taxanes are the only cytotoxic chemotherapeutic agents proved to prolong the survival in patients with castration-resistant prostate cancer. However, because of intrinsic and acquired resistances to taxanes, their therapeutical efficiencies are modest, bringing only a few months of

Paclitaxel alleviated liver injury of septic mice by alleviating inflammatory response via microRNA-27a/TAB3/NF-κB signaling pathway.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Excessive inflammatory response and apoptosis play an important role in the sepsis-induced liver injury. Paclitaxel, a diterpene alkaloid of Taxus brevifolia, is widely used as an anti-tumor drug and shows protective effects on acute lung and kidney injury. However, whether it has a protective

The relationship between an endangered North American tree and an endophytic fungus.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND The Florida torreya (Torreya taxifolia) began a catastrophic decline in the late 1950s and is now the rarest tree in North America for which a full species designation has been established. The trees have common plant disease symptoms, but the reason for the decline has never been

Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-κB-p53-caspase-3 pathway.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Paclitaxel, isolated from Taxus brevifolia, is considered to be an efficacious agent against a wide spectrum of human cancers, including human cervical cancer. However, dose-limiting toxicity and high cost limit its clinical application. Curcumin, a nontoxic food additive, has been reported to

Modulation of programmed cell death by medicinal plants.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Programmed cell death (apoptosis), a form of cell death, described by Kerr and Wyllie some 20 years ago, has generated considerable interest in recent years. The mechanisms by which this mode of cell death (seen both in animal and plant cells), takes place have been examined in detail. Extracellular

Natural products as a rich source of tau-targeting drugs for Alzheimer's disease.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia, affecting more than 5.4 million people in the USA. Although the cause of AD is not well understood, the cholinergic, amyloid and tau hypotheses were proposed to explain its development. Drug discovery for

Characteristics, Properties and Analytical Methods of Paclitaxel: A Review.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Paclitaxel is a diterpenoid pseudoalkaloid, isolated from Taxus brevifolia, and is largely used as an antitumoral drug. The formulation of paclitaxel known as Taxol® employs a mixture of Cremophor EL and dehydrated ethanol, due the low drug water solubility. However, Taxol® causes some unwanted side

Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Dealing with cancer is of importance due to enhanced incidence rate of this life-threatening disorder. Chemotherapy is an ideal candidate in overcoming and eradication of cancer. To date, various chemotherapeutic agents have been applied in cancer therapy and paclitaxel (PTX) is one of them. PTX is

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Herbal & Natural Medicine

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