udp glucose/השמנת יתר חולנית

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בחר סוג מיון

14 תוצאות

Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

In the present study, the effects of insulin and contraction on glycogen synthase (GS) kinetic properties and phosphorylation were investigated in epitrochlearis muscles from lean and obese Zucker rats. Total GS activity and protein expression were ~15% lower in epitrochlearis from obese rats

Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Insulin stimulates glycogen synthase (GS) through dephosphorylation of serine residues, and this effect is impaired in skeletal muscle from insulin-resistant [obese and type 2 diabetic (T2DM)] subjects. Exercise also increases GS activity, yet it is not known whether the ability of exercise to

GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

GPR105, a G protein-coupled receptor for UDP-glucose, is highly expressed in several human tissues and participates in the innate immune response. Because inflammation has been implicated as a key initial trigger for type 2 diabetes, we hypothesized that GPR105 (official gene name: P2RY14) might

Regulation and function of yeast PAS kinase: a role in the maintenance of cellular integrity.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

The inability to coordinate cellular metabolic processes with the cellular and organismal nutrient environment leads to a variety of disorders, including diabetes and obesity. Nutrient-sensing protein kinases, such as AMPK and mTOR, play a pivotal role in metabolic regulation and are promising

More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Lithium's impact on glucose metabolism was compared with that of insulin in isolated rat soleus muscle. Lithium chloride (20 mmol/l) induced a 4.8-fold more pronounced increment over basal glycogen synthase activity than insulin (10 nmol/l) (nmol UDP-glucose into glycogen in synthase activity

Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 diabetes.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines [UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc)] is an important mechanism by which hyperglycemia causes insulin resistance. This study was performed to test

Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

It has been proposed that the hexosamine pathway acts as a nutrient-sensing pathway, protecting the cell against abundant fuel supply, and that accumulation of hexosamines represents a biochemical mechanism by which hyperglycemia and hyperlipidemia induce insulin resistance. We hypothesized that if

Evidence that processes other than gluconeogenesis may influence the ratio of deuterium on the fifth and third carbons of glucose: implications for the use of 2H2O to measure gluconeogenesis in humans.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

OBJECTIVE The deuterated water method uses the ratio of deuterium on carbons 5 and 2 (C5/C2) or 3 and 2 (C3/C2) to estimate the fraction of glucose derived from gluconeogenesis. The current studies determined whether C3 and C5 glucose enrichment is influenced by processes other than

The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Epigenetic changes in response to external stimuli are fast emerging as common underlying causes for the pre-disposition to adult disease. Prenatal androgenization is one such model that results in reproductive and metabolic features that are present in conditions such as polycystic ovary syndrome

Preserved direct hepatic insulin action in rats with diet-induced hepatic steatosis.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Recent in vivo studies have demonstrated a strong negative correlation between liver triglyceride content and hepatic insulin sensitivity, but a causal relationship remains to be established. We therefore have examined parameters of direct hepatic insulin action on isolated steatotic livers from

Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Natural killer T (NKT) cells in adipose tissue (AT) contribute to whole body energy homeostasis.Inhibition of the glucosylceramide synthesis in adipocytes impairs iNKT cell activity.Glucosylceramide biosynthesis pathway is

An In Vitro Model to Probe the Regulation of Adipocyte Differentiation under Hyperglycemia.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

BACKGROUND The aim of this study was an in vitro investigation of the effect of high glucose concentration on adipogenesis, as prolonged hyperglycemia alters adipocyte differentiation. METHODS 3T3-L1 preadipocytes differentiated in the presence of varying concentrations of glucose (25, 45, 65, 85,

High-yield anthocyanin biosynthesis in engineered Escherichia coli.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Anthocyanins are red, purple, or blue plant water-soluble pigments. In the past two decades, anthocyanins have received extensive studies for their anti-oxidative, anti-inflammatory, anti-cancer, anti-obesity, anti-diabetic, and cardioprotective properties. In the present study, anthocyanin

Liver glucose metabolism in humans.

רק משתמשים רשומים יכולים לתרגם מאמרים

התחבר הרשם

Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism is involved in glycosylation reactions and connected with fatty acid metabolism. The liver receives dietary carbohydrates

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Herbal & Natural Medicine

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