The present invention provides a compound of formula A: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein B, Q, R.sup.1, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and Z are as defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

Anandan; Sampath-Kumar

Aulakh; Virender Singh

Fenaux; Martijn

Lin; Xiaodong

Mao; Liang

Saunders; Oliver

Sweeney; Zachary Kevin

Yokokawa; Fumiaki

Zhong; Weidong

Novartis AG

2'-Ethynyl nucleoside derivatives for treatment of viral infections

The present invention provides a compound of formula A: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein B, Q, R.sup.1, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and Z are defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

2'-ethynyl nucleoside derivatives for treatment of viral infections

The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light. The invention includes novel strains of WNV for use in producing a vaccine.

yellow fever/שלשול

2'-Ethynyl nucleoside derivatives for treatment of viral infections

2'-ethynyl nucleoside derivatives for treatment of viral infections

RNA virus vaccines and methods

המאגר השלם ביותר של צמחי מרפא המגובה על ידי המדע