Diagnostic Test of Choice for HELPS Syndrome
キーワード
概要
説明
The treatment of HELPS syndrome begins with the correct diagnosis. Some patients are able to localize the side of their symptoms in HELPS syndrome while others are unable to. The purpose of this study is to prospectively study which of the following is the diagnostic test of choice for patients who are unable to localize their HELPS: 1. CISS MRI sequences, 2. interictal laryngoscopy, and 3. unilateral and contralateral Botox injections separated 3-months apart.
Both neuroradiologist and otolaryngologist will be blinded to the outcome of surgery and be asked "based on your diagnostic test, which side do you believe we should perform MVD surgery?"
日付
最終確認済み: | 03/31/2017 |
最初に提出された: | 04/09/2017 |
提出された推定登録数: | 04/20/2017 |
最初の投稿: | 04/24/2017 |
最終更新が送信されました: | 04/20/2017 |
最終更新日: | 04/24/2017 |
実際の研究開始日: | 04/29/2017 |
一次完了予定日: | 04/29/2018 |
研究完了予定日: | 10/29/2018 |
状態または病気
介入/治療
Diagnostic Test: HELPS Syndrome unable to lateralize contractions
Diagnostic Test: HELPS Syndrome unable to lateralize contractions
Diagnostic Test: HELPS Syndrome unable to lateralize contractions
段階
アームグループ
腕 | 介入/治療 |
---|---|
HELPS Syndrome unable to lateralize contractions Each patient will have the following 3 diagnostic pre-operative tests: i) MRI (CISS sequence), ii) video laryngoscopy, and iii) sequential Botox injections in their throat (left side and then 3 months later on the right side). | Diagnostic Test: HELPS Syndrome unable to lateralize contractions Compare pre-operative MRI diagnosis to intra-operative findings on if both are in agreement |
適格基準
研究の対象となる年齢 | 18 Years に 18 Years |
研究に適格な性別 | All |
サンプリング方法 | Non-Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - Patients diagnosed with HELPS as described in our initial publication (Honey et al. 2016) - Patients unable to localize the side of their HELPS syndrome Exclusion Criteria: - Unable to provide informed consent |
結果
主な結果の測定
1. Pre-Operative CISS MRI (One month before surgery) compared to Intraoperative Findings [Pre-Operative and Intra-Operative]
2. Pre-Operative Interictal Laryngoscopy (One month before surgery) compared to Intraoperative Findings [Pre-Operative vs. Intra-Operative]
3. Pre-Operative 3 and 6-month Botox Injections compared to Intraoperative Findings [Pre-operative 3 and 6 months vs. Intra-Operative]