High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury
キーワード
概要
説明
The aim of this research is to determine the metabolic responses to a mixed-meal tolerance test following a bout of HIIT and MICT in persons with chronic paraplegia. The hypothesis is that HIIT and MICT will be more effective at reducing the total triglyceride responses compared to a resting control condition.
Preliminary measurements:
Preliminary testing will include anthropometric measurements of supine length, weight, waist and hip circumferences, and resting blood pressure. There will also be an assessment of resting metabolic rate, sub-maximal and maximal exercise capacity, and a HIIT familiarisation session. All of the exercise protocols will take place on an arm crank ergometer at the University of Bath.
Physical activity monitoring:
For 7 days, participants will be fitted with a physical activity monitor (Actiheart™). Participants should not make any conscious changes to their normal lifestyle habits/routines during this period.
Main trial days:
In the 2 days prior to the main trial day, participants will be asked to record their food and drink intake and 48 hours before they should refrain from performing any strenuous physical activity. In the 24 hours prior participants should also refrain from consuming any alcohol or caffeine.
Following a 10-hour overnight fast, an expired gas sample and venepuncture blood sample will be taken prior to exercise. Participants will then perform a bout of HIIT, MICT or a resting control condition. Following exercise, a cannula will be inserted into a vein and baseline blood sample(s) taken for analysis of metabolic markers.
The participant will then be asked to consume a smoothie, consisting of peanut butter, banana, coconut oil, sugar, and chocolate-flavoured whey protein powder. The meal should be consumed within 10 minutes and blood samples will be taken from the cannula at 15, 30, 45 60, and 90 minutes and then at every hour for 6 hours after consumption of the meal to monitor changes in metabolic and inflammatory markers. Expired gas samples will also be taken hourly and indirect calorimetry will be used to estimate relative fat and carbohydrate metabolism in response to the meal.
日付
| 最終確認済み: | 06/30/2019 |
| 最初に提出された: | 07/02/2019 |
| 提出された推定登録数: | 07/04/2019 |
| 最初の投稿: | 07/07/2019 |
| 最終更新が送信されました: | 05/16/2020 |
| 最終更新日: | 05/18/2020 |
| 実際の研究開始日: | 03/31/2018 |
| 一次完了予定日: | 12/30/2020 |
| 研究完了予定日: | 12/30/2020 |
状態または病気
介入/治療
Other: Exercise
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| No Intervention: Control No exercise - 30-min of rest | |
| Experimental: High-intensity interval training 8 x 60 s intervals at 70% peak power output (intersperesed with 60 s recovery intervals at 10% peak power output) | |
| Experimental: Moderate-intensity continous training 25 min at 45% peak power output |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Individuals with a chronic (>12 months post-injury) SCI below T2 - Individuals who spend >75% of their waking day in a wheelchair - Weight stable (weight not changed by >3% over the last 3 months) Exclusion Criteria: - Individuals who an acute (<12 months post-injury) SCI - Individuals who spend <75% of their waking day in a wheelchair - Individuals on type-2 diabetes medication - Individuals with a peanut allergy - Individuals who self-report use of lipid-lowering agents - Individuals self-reporting active medical issues (pressure sores, urinary tract infections, cardiac disorders, musculoskeletal complaints of the upper extremities, or cardiovascular contraindications to exercise testing) - Individuals who report uncontrolled or regular autonomic dysreflexia |
結果
主な結果の測定
1. Postprandial triglyceride concentrations [6 hours]
二次的な結果の測定
1. Postprandial glucose concentrations [6 hours]
2. Postprandial insulin concentrations [6 hours]
3. Postprandial non-esterified fatty acid concentrations [6 hours]
4. Postprandial cholesterol, HDL, and LDL concentrations [6 hours]
5. Postprandial substrate oxidation [6 hours]
6. Rating of Perceived Exertion [MICT: End of Warm-Up, 6 minutes 15 seconds, 12 minutes 30 seconds, 18 minutes 45 seconds, End of Exercise. HIIT: End of Warm-Up, 8 minutes, 12 minutes, 16 minutes, 20 minutes)]
7. Heart Rate [MICT: End of Warm-Up, 6 minutes 15 seconds, 12 minutes 30 seconds, 18 minutes 45 seconds, End of Exercise. HIIT: End of Warm-Up, 8 minutes, 12 minutes, 16 minutes, 20 minutes)]
8. Affect [MICT: End of Warm-Up, 6 minutes 15 seconds, 12 minutes 30 seconds, 18 minutes 45 seconds, End of Exercise. HIIT: End of Warm-Up, 8 minutes, 12 minutes, 16 minutes, 20 minutes)]
9. Exercise Enjoyment [30 minutes post-exercise]
10. Self-efficacy [30-minutes post-exercise]
