[Clinical epidemic interaction of reflux esophagitis and Helicobacter pylori infection in children and adolescents].
キーワード
概要
BACKGROUND
the role of Helicobacter pylori (HP) in the development of gastroesophageal reflux disease (GERD) stays disputable.
OBJECTIVE
to determine clinical-epidemic correlations between reflux-esophagitis (RE) and HP in children and adolescents.
METHODS
300 children and adolescents 12-18 years old with RE were examined. HP was diagnosed by histological (Giemza stain with the evaluation of dissemination grade) and rapid urease test. Subjective symptoms (heartburn, abdominal pain, other dyspeptic and astenovegetative complaints) and possible predisposing factors (frequent stresses, carbohydrates in food, education of parents, chronic nidi of infection, presence of pets at home) were analyzed by questionnaire.
RESULTS
HP infection was found in 45% children and adolescents with RE, and it does not increase the risk of erosive esophageal defects. Clinical symptoms don't connect with microorganism in examined patients. The frequency of HP infection decreases with the increase of disease anamnesis and presence of pets, increases in cases of primary carbohydrate food and does not associate with stress, educational level of parents and chronic nidi of infection.
CONCLUSIONS
The development of RE does not connect with HP, but the course of disease has certain peculiarities in conditions of HP infection.
