[EVALUATION OF PARAMETERS OF HEMOSTASIS IN THE THIRD TRIMESTER IN PREGNANT WOMEN WITH CONGENİTAL HEMORRHAGIC DIATHESIS].

The aim is to study the coagulogram indices in the III trimester of pregnancy in women with hemophilia and von Willebrand disease. Twenty-seven pregnant women with hereditary coagulopathies of mild and moderate form (mean age 27.9±3.3 years) in the third trimester of pregnancy were examined. Of the examined 12 women - carriers of hemophilia A and B, 15 - with Willebrand disease (BV). Clinico-laboratory examination, clinical and biochemical blood tests were carried out. Coagulologic examination was performed on 17 parameters. The mean gestation period was 38.5±1.04 weeks. In 81.5% of cases, the headache was determined, in 18.5% - the pelvic presentation. Pregnancy was complicated by placental insufficiency in 51.8% of cases, in 14.8% of cases there was a lag in the development of the fetus. In pregnant women with hemophilia prothrombin time was increased: by 18.9% and by 8.8% - in women with BV. In the third trimester of pregnancy, a significant increase in APTT, the duration of bleeding (according to Dike), and the prolongation of Lee White's coagulation time in pregnant women with hemophilia are noted in both groups of women under analysis. In pregnant women with congenital hemorrhagic diathesis, coagulogram parameters should be determined in each trimester.