Eksperimental'naya i Klinicheskaya Farmakologiya 2014
[Influence of melatonin and diclofenac on circadian rhythm of locomotor activity in rats with local inflammatory arthritis].
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概要
Inflammatory arthritis is accompanied by disorganization of the circadian rhythm of locomotion in rats. Control saline injections increased the rhythm disturbances. Chronic administration of melatonin (5 mg/kg) attenuated these chronopathological shifts. Diclofenac demonstrated much lower positive chronopharmacological activity than did melatonin.