Interaction of cyclomaltononaose (delta-CD) with several drugs.
キーワード
概要
The effects of delta-cyclodextrin (delta-CD; cyclomaltononaose) on solubility of 14 drugs that are slightly soluble or insoluble in water were studied and compared with those of conventional cyclodextrins (CDs) such as alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), and gamma-cyclodextrin (gamma-CD). In general, delta-CD had a weak complex-forming ability with the drugs examined in comparison with beta-CD and gamma-CD. However, in the case of digitoxin, delta-CD enhanced solubility of the guest molecules. To determine the mechanism of inclusion complex formation of delta-CD with digitoxin, the interaction of both drugs was investigated by the solubility method and spectroscopic methods such as ultraviolet (UV) and 1H-NMR (nuclear magnetic resonance). The changes in chemical shift (1H) and hypsochromic shift of UV suggested that digitoxin was partially included in the cavity of delta-CD.