PP006. The comparison of serum VEGF and sFlt-1 on preeclampsia and eclampsia pregnant woman before and after delivery at Ulin Hospital, Banjarmasin, Indonesia.
キーワード
概要
BACKGROUND
Preeclampsia is the main cause of maternal morbidity and mortality at Indonesia. In 2010, 228 maternal deaths occur in 100,000 live birth. Ulin Hospital, Banjarmasin, a tertiary care hospital has high prevalence of preeclampsia and eclampsia (22%). Vascular angiogenesis has a role on pathogenesis of preeclampsia, including angiogenic factor and anti-angiogenic factor like VEGF and sFlt-1.
OBJECTIVE
To evaluate changes of sFlt-1 and VEGF levels on preeclampsia and eclampsia woman before and after delivery.
METHODS
This is a cross sectional research, which include 30 pregnant women with preeclampsia and eclampsia at Ulin Hospital, Banjarmasin, whom pregnancy was terminated vaginaly or abdominaly. Every patient was checked for the serum level of sFlt-1 and VEGF before and 3days after delivery.
RESULTS
There are significant changes of the serum level sFlt-1 and VEGF before and after delivery. Serum sFlt-1 mean value decrease significantly after delivery (18251.4pg/ml vs 1193.9pg/ml; p<0.0001). Serum VEGF mean value increase significantly after delivery (50.4pg/ml vs 836.1pg/ml; p<0.0001). Mean value of the angiogenic factor before and after delivery was not significantly different between early-onset PE, late-onset PE and eclampsia.
CONCLUSIONS
There are significant changes of the angiogenic factors (sFlt-1 and VEGF) before and 3days after delivery.
