Die Pharmazie 2004-Apr
Synthesis and anti-inflammatory effect of lipophilic derivatives of threo-DL-phenylserine in rat experimental edema.
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概要
Novel N- and O-acyl derivatives of threo-DL-phenylserine containing lipophilic long chain carboxylic or aryl(sulfon)amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 24 h.