Infection and Immunity 1999-Nov
Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice.
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概要
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.