18 alpha glycyrrhetinic acid/悪性腫瘍

Gap junctions (GJs) serve the principal role in the antineoplastic (cytotoxicity and induced apoptosis) effect of chemical drugs. The aim of the present study was to determine the effect of GJ intercellular communication (GJIC) composed of connexin 43 (Cx43) on adriamycin cytotoxicity in breast

OBJECTIVE To estimate the bystander effect mediated by herpes simplex virus-thymidine kanase/ganciclovir (HSV-TK/GCV) suicide gene therapy approach on PC-3m, a prostate cancer cell line, to explore the role of connexin (Cx) mediated gap junctional intercellular communication (GJIC) in the procedure

Natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. Recently, nonsteroidal anti-inflammatory drug (NSAID) activated gene-1 (NAG-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and

Since 1986, there have been reports in the literature that glycyrrhizin (GL), 18 alpha-glycyrrhetinic acid (18 alpha-GA) and 18 beta-glycyrrhetinic acid (18 beta-GA) can inhibit the growth of some murine tumours. Recently, testing the activity of GL and 18 alpha-GA on human tumour cells, we observed

In tumor models, the killing by ganciclovir of a fraction of tumor cells transfected with the thymidine kinase (TK) gene has been shown to induce complete regression of the tumor. The mechanism responsible for this bystander effect is thought to be the diffusion of toxic metabolites or apoptotic

Platinum agents are widely used in the chemotherapy of testicular cancer. However, adverse reactions and resistance to such agents have limited their application in antineoplastic treatment. The aim of the present study was to determine the role of gap junction intercellular communication (GJIC)