Behavioral intervention with diet including 4 servings per week of red meat, 3 servings per week of processed meat, and 1 servings per week of poultry, for a total amount of 900 g per week of meat.

Behavioral intervention including diet with 4 servings per week of red meat, 3 servings per week of processed meat, and 1 servings per week of poultry, for a total amount of 900 g per week of meat with a dietary supplement of 100 mg/day of alpha-tocopherol in the form of tablet

Behavioral intervention with diet excluding fresh and processed meat, poultry but including 3 servings per week of any type of fish, excluding shellfish

Nutrition Aspect of Cancer

Diet Modification

Cancer of Colon

Diet including 4 servings per week of red meat (1 serving = 150 g), 3 servings per week of processed meat (1 serving = 50 g), and 1 servings per week of poultry (1 serving = 150 g), for a total amount of 900 g per week of meat.

Meat-based diet

Dietary intervention like the MBD with supplementation of alpha-tocopherol at a dosage of 100 mg/die. Available evidence suggests that alpha-tocopherol may help prevent colon cancer by decreasing the formation of mutagens arising from the oxidation of faecal lipids, by decreasing oxidative stress in the epithelial cells of the colon and by molecular mechanisms that influence cell death, cell cycle and transcriptional events (Pierre 2013, Bastide 2016, Bastide 2017, Diallo 2016). It is important to note that 200 mg/day of tocopherol was administered to 20,000 women for 10 years without side effects (Lee et al.,2005).

Meat-based diet supplemented with alpha-tocopherol (MBD-T)

Diet excluding fresh and processed meat, poultry but including 3 servings per week of any type of fish, excluding shellfish (1 serving = 150 g), for a total amount of 450 g per week. Diet will contain other sources of proteins (e.g. eggs, dairy, legumes/beans). There is suggestive evidence that fish and vegetable consumption has protective effects against CRC (Vieira et al., 2017).

Pesco-vegetarian diet

Unit of Clinical Nutrition, University Hospital of Careggi

Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer

Faecal Microbiome as Determinant of the Effect of Diet on Colorectal-cancer Risk: Comparison of Meat Based Versus Pesco-vegetarian Diets (MeaTIc)

Decrease (<25%) of DNA damage by faecal water (genotoxicity), using comet assay in a cellular model

Changes of microbiome and the relative metabolomics profiles from baseline

Global and specific peroxidation of omega-3 and omega-6 of the faecal water change from baseline

Pro- and anti-inflammatory profile's change from baseline

Oxidative stress profile's change from baseline

Francesco Sofi

Associate Professor of Clinical Nutrition

Azienda Ospedaliero-Universitaria Careggi

Randomized parallel open dietary intervention study with 3 arms of intervention

In this trial blinding of participants and investigators will not be possible because of obvious differences between the intervention diets

Group case: modified ketogenic diet to reduce at least 20% saturated fat, up> 50% of the acid supply monounsaturated, increasing> 50% polyunsaturated fatty acid content and a lower ratio w6 / w3 at least 50% compared to classic diet used by the control group

Epilepsy

Cardiovascular Disease

Non-alcoholic Fatty Liver Disease

Quality of Life

ketogenic diet

Nagila Raquel Teixeira Damasceno

Impact of Ketogenic Diet on Lipoproteins in Refractory Epilepsy

Classic Ketogenic Diet and Modified: Evaluation of the Therapeutic Potential and Impact on the Oxidative Profile, Lipidomic, Inflammatory and Size of Lipoproteins in Children and Adolescents With Refractory Epilepsy

age, income, disease, parent´s education, use of drugs and supplements, type of seizures, questions about quality of life

phase angle mass by impedance bioeletrical

Food record applied during 3 days to each time

Concentration of B-hydroxybutirate in plasma. Determination with kit Ranbut (Randox Laboratories Limited, Reino Unido).

Concentration in plasma. Determination with kit NEFAS(Randox Laboratories Limited, Reino Unido)

alpha tocopherol/necrosis

Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer

Impact of Ketogenic Diet on Lipoproteins in Refractory Epilepsy

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