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ページ 1 から 24 結果
Indole amide compound as inhibitor of necrosis
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TECHNICAL FIELD
The present invention relates to an indole amide compound of Formula (1), a pharmaceutically acceptable salt or isomer thereof, and a composition and a method of preparing a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases comprising
Interleukin-1 and tumor necrosis factors-.alpha. modulators, syntheses of said modulators and methods of using modulators
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FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
Cyclic amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Cyclic amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF, or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Cyclic amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein. TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Cyclic amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Immunotherapeutic aryl amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Immunotherapeutic aryl amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Immunotherapeutic aryl amides
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BACKGROUND OF THE INVENTION
The present invention relates a method of reducing levels of TNF.alpha. in a mammal and to compounds and compositions useful therein.
TNF.alpha., or tumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear phagocytes in response to various
Immunotherapeutic imides/amides
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BACKGROUND OF THE INVENTION
The present invention relates to a method of reducing levels of TNF.alpha. and inhibiting phosphodiesterase in a mammal and to compounds and compositions useful therein.
TNF.alpha., or rumor necrosis factor .alpha., is a cytokine which is released primarily by mononuclear
Necrosis inhibitors
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INTRODUCTION
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor-.kappa.B (NF-.kappa.B)
Necrosis inhibitors
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INTRODUCTION
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor .kappa.B (NF-.kappa.B)
Necrosis inhibitors
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INTRODUCTION
Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor .kappa.B (NF-.kappa.B)
Necrosis inhibitors
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Tumor necrosis factor alpha (TNF-.alpha.)-induced NF-.kappa.B activation plays a central role in the immune system and inflammatory responses. Receptor-interacting protein 1 (RIP1) is a multi-functional signal transducer involved in mediating nuclear factor .kappa.B (NF-.kappa.B) activation,
Interleukin-1 and tumor necrosis factor-.alpha. modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
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FIELD OF THE INVENTION
The invention relates to chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. The invention also relates to methods of synthesizing
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