5 結果
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a method for diagnosing for abnormalities in the biosynthesis of type III procollagen in cultured skin fibroblasts. More particularly, this invention relates to a method for diagnosing for aneurysms which comprises
BACKGROUND OF THE INVENTION
1. Field
The present invention relates to novel nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel nitrile derivatives of formula (I)
2. Description
Cysteine proteases have been viewed as lysosomal mediators of
BACKGROUND OF THE INVENTION
Cysteine proteases have been viewed as lysosomal mediators of terminal protein degradation. Several newly discovered members of this enzyme class, however, are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology and thus
PRIORITY TO RELATED APPLICATIONS
This application claims the benefit of European Patent Application No. 11188728.7, filed Nov. 11, 2011, which is hereby incorporated by reference in its entirety.
SUMMARY OF THE INVENTION
The invention relates to a process for the preparation of a proline derivative
FIELD OF THE INVENTION
The present invention relates to novel beta-amino acid nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel beta-amino acid nitrile derivatives of formula (I) ##STR1##
wherein R.sup.1 represents hydrogen, aryl,