six sessions of fractional carbon dioxide laser will be done for 10 patients with alopecia areata

six sessions of fractional carbon dioxide laser will be done for 10 patients with alopecia areata followed immediately by topical application of triamcinolone acetonide (10mg/ml)

six sessions of fractional carbon dioxide laser will be done for 10 patients with alopecia areata followed immediately by topical application of autologous platelet rich plasma

six sessions of fractional carbon dioxide laser will be done for 10 patients with alopecia areata followed immediately by topical application of vitamin D solution

Alopecia Areata

six sessions of fractional carbon dioxide laser will be done for alopecia areata lesions

fractional carbon dioxide laser alone

six sessions of fractional carbon dioxide laser will be done for 10 patients with alopecia areata followed immediately by topical application of triamcinolone acetonide

Triamcinolone Acetonide 10mg/mL

platelet rich plasma

vitamin D solution

Assiut University Hospital

Efficacy of Fractional CO2 Laser as a Mono- or Adjuvant Therapy for Alopecia Areata

Efficacy of Fractional CO2 Laser Alone and as Transepidermal Drug Delivery for Different Modalities of Treatment in Alopecia Areata

hair regrowth in each group in response to treatment (hair density ) expressed in follicles/ cm2

A Ghazally

principal investigator

Assiut University

Group 1: included 10 psoriatic patients will be treated with ethosomal preparation of anthralin. Patients will be treated with this preparation with short contact (only one hour) daily up to 8 weeks.

Group 2: included 10 psoriatic patients will be treated with liposomal preparation of anthralin. Patients will be treated with this preparation with short contact (only one hour) daily up to 8 weeks.

Psoriasis Vulgaris

once daily with short contact topical application

ethosomal preparation of anthralin

liposomal preparation of anthralin

Formulation and Clinical Evaluation of Ethosomal and Liposomal Preparations of Anthralin in Psoriasis

PASI combines the assessment of the severity of psoriatic lesions and the area affected into a single score in the range 0 (no disease) to 72 (maximal disease). PASI will be measured before and after treatment to assess the efficacy of therapy.Steps in generating PASI score
Divide body into four areas: head, arms, trunk, and legs .
Generate an average score for the erythema, thickness, and scaling for each of the 4 areas , each graded on a 0-4 scale (0 = clear, 1= slight,2= mild, 3=moderate, 4=severe).
Sum scores of erythema, thickness, and scale for each area.
Generate a percentage for skin covered with psoriasis for each area and convert that to a 0-6 scale (0 = 0%; 1 =,10%; 2 = 10-,30%; 3 = 30-,50%; 4 = 50-
,70%; 5 = 70-,90%; 6 = 90-100%).
Multiply score of item (c) above times item (d) above for each area and multiply that by 0.1, 0.2, 0.3, and 0.4 for head, arms, trunk, and legs, respectively.
Add these scores to get the PASI score.

hematoxylin and eosin staining of skin biopsies from psoriatic lesions before and after treatment will be done.

by recording any possible adverse events like itching, burning sensation, staining of skin or clothes and erythema.

at the end of treatment, it will be evaluated by patient's self assessment of the degree of improvement of psoriasis

digital photography of the lesions before and after treatment using a 14.1 megapixels Sony DSC- W 390 digital camera will be done for each patient to assess any changes in clinical appearance of psoriatic lesions and evaluate the response of treatment.

Eman Kamal

Principle investigator

The aim of the present study was to develop an ethosomal delivery system anthralin and evaluate its effectiveness and safety in treatment of psoriasis and comparing it with liposomal delivery system anthralin.

Psoriasis patients treated with dithranol

Non-Psoriasis patients undergoing surgery for skin lesions. Tumor-adjacent skin is collected for control purposes.

Psoriasis

Klinikum Klagenfurt am Woerthersee

Study on the Therapeutic Mechanisms of Dithranol Treatment in Patients With Chronic Plaque Psoriasis

Study on the Therapeutic Mechanisms of Dithranol Treatment With Regard to Pro- and Contra-inflammatory Factors, microRNA as Well as Lymph and Blood Vessels in Patients With Chronic Plaque Psoriasis

anthralin/inflammation

Efficacy of Fractional CO2 Laser as a Mono- or Adjuvant Therapy for Alopecia Areata

Formulation and Clinical Evaluation of Ethosomal and Liposomal Preparations of Anthralin in Psoriasis

Study on the Therapeutic Mechanisms of Dithranol Treatment in Patients With Chronic Plaque Psoriasis

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