anxiolytic/癲癇性発作

BACKGROUND OF THE INVENTION The present invention relates to certain novel imidazo[4,5-b]pyridines useful as anxiolytic and anticonvulsant agents, by virtue of their ability to bind to the benzodiazepine receptors and inhibit electrically or chemically induced seizures. The preparation of fused

This is a continuation of international application Ser. No. PCT/DK92/00183, filed Jun. 12, 1992. The present invention relates to a class of piperidine compounds having anxiolytic effect and potently binding to the sigma receptors and therefore being useful in the treatment of psychic and

The present invention relates to a class of piperidine compounds having anxiolytic effect, and potently binding to the sigma receptors and therefore being useful in the treatment of psychic and neurologic disorders. Various related compounds are known from the prior art. So, U.S. Pat. Nos. 3,686,186

The present invention relates to a class of piperidine compounds having anxiolytic effect and potently binding to the sigma receptors and therefore being useful in the treatment of psychic and neurologic disorders. Various related compounds are known from the prior art. So, U.S. Pat. Nos. 3,686,186

The present invention relates to a class of piperidine compounds having anxiolytic effect and potently binding to the sigma receptors and therefore being useful in the treatment of psychic and neurologic disorders. Various related compounds are known from the prior art. So, U.S. Pat. Nos. 3,686,186

CROSS REFERENCE TO RELATED APPLICATIONS This application claims priority under 35 U.S.C. .sctn. 119 from GB Application No. 0223349.2 filed Oct. 8, 2002. The present invention relates to a class of substituted imidazo-pyridazine derivatives and to their use in therapy. More particularly, this

CROSS REFERENCE TO RELATED APPLICATIONS This application is a U.S. National Phase application under 35 U.S.C. .sctn. 371 of PCT Application No. PCT/GB2003/004685, filed Oct. 29, 2003, which claims priority under 35 U.S.C. .sctn. 119 from GB Application No. 0225923.2, filed Nov. 6, 2002, GB

FIELD OF THE INVENTION The present invention relates to diphenethylamine derivatives which can be used as highly active analgesics, diuretics, anxiolytics, for the treatment of neurodegenerative, psychiatric and neuropsychiatric disorders, and also as anti-itch, anti-addiction, anti-inflammatory,

SUMMARY OF THE INVENTION The present invention relates to compounds of the formula ##STR2## wherein Ra is hydrogen or halogen; Rb is --OR.sup.1 or --NR.sup.2 R.sup.3 ; R.sup.1 is an unsubstituted lower alkyl or a lower alkyl substituted by hydroxy, lower alkoxy, amino, lower alkylamino, di(lower

SUMMARY OF THE INVENTION The present invention relates to compounds of the formula ##STR2## wherein Ra is hydrogen or halogen; Rb is --OR.sup.1 or --NR.sup.2 R.sup.3 ; R.sup.1 is an unsubstituted lower alkyl or a lower alkyl substituted by hydroxy, lower alkoxy, amino, lower alkylamino, di(lower