aspartate amino transferase/breast neoplasms

BACKGROUND Generation of novel spontaneous ER positive mammary tumor animal model from heterozygous NIH nude mice. METHODS Using brother-sister mating with pedigree expansion system, we derived a colony of heterozygous breeding females showing ER-Positive tumors around the age of 6 months. Complete

Fisetin, a natural flavonoid found in a variety of edible and medical plants, has been suggested to inhibit the proliferation of various tumor cells and to induce apoptosis. However, the effects of fisetin on breast cancer have rarely been reported and the underlying mechanism is still undefined.