The biosynthesis of gymnomitranes in the liverworts Reboulia hemisphaerica (L.) Raddi and Bazzania trilobata (L.) Gray was investigated. Labelling experiments with 1-13C-, 2-13C- and 6,6-D2 glucose, 2,2-D2- and 4,4-D2 mevalolactone and tissue cultures of the liverworts were carried out.