benzopyrone/breast neoplasms

The frequency of secondary lymphedema occurrence following breast cancer therapy has been decreasing since new conservative surgical treatment and radiotherapy are applied. However, about 20% of female patients treated for breast cancer will develop mild swelling of the arm or forearm and seek

Lymphoedema of the arm is a disabling complication of surgery for cancer of the breast. It occurs in a significant proportion of patients and tends to occur later after the operation. Radiation increases the incidence. It needs to be differentiated for tumour recurrence and venous obstruction.

Treatment of primary or secondary lymphedema includes essentially complex decongestive physiotherapy. For many years now, drugs active in reducing volume of lymphedema are prospected. But few studies are available. Only few drugs have been tested. Diuretics have been the first to be used with short

Coumarin (1,2-benzopyrone) is a natural compound that has been used as a fragrance in the food and perfume industry and could have therapeutic usefulness in the treatment of lymphedema and different types of cancer. Several previous pharmacokinetic studies of coumarin have been performed in humans,

UNASSIGNED New benzopyrone derivatives such as Schiff's like compounds, acetohydrazides or substituted with oxadiazole or pyrazole heterocycles were synthesized from parent acid hydrazide compound 3. UNASSIGNED Structures of the synthesized compounds were elucidated using IR, NMR and mass

Synthetic coumarin (benzopyrone) was launched in France in 1988 for the adjuvant therapy of lymphoedema of the upper limb following radiosurgical treatment of breast cancer. Further to the reporting of hepatic reactions, a national survey has been carried out. The survey dealt with 22 cases reported

Curcumin has been well studied for its anti-oxidant, anti-inflammatory, and anti-cancer action. Its potential as a therapy is limited due to its low bioavailability and rapid metabolism. To overcome these challenges, investigators are developing curcumin analogs, nanoparticle formulations, and

Coumarin class of organic compounds consists of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and gammabenzopyrones; with coumarin class of compounds belonging to alpha-benzopyrones. Since the last few years, coumarins were

Coumarin has a place with a class of lactones which are fundamentally comprising of a benzene ring fused to αpyrone ring, known as benzopyrones. It likewise has a conjugated framework with electron rich and good charge-transport properties. It is delivered by plants to shield themselves from

Several phlebotropic drugs, or edema-protecting drugs, are available, the most important of which are found in the gamma-benzopyrone family (flavonoids). gamma-Benzopyrones can be plant extracts, semisynthetic preparations, or synthetic preparations. This family is divided into two different groups:

BACKGROUND Lymphoedema is the accumulation of excess fluid in the body caused by obstruction of the lymphatic drainage mechanisms. It can be caused by a number of factors, including congenital predisposition, parasitic infection or surgery. Lymphoedema is chronic and progressive and affects a