broad bean/悪性腫瘍

Purified field bean protease inhibitor (FBPI) was labeled with 99mTcO4- to ascertain its ability to locate tumors in tumor-bearing rat models. The labeling was done with Sn2+ as a reducing agent and the yield was 95%. It was stable for 2 hr at ambient temperature. The biodistribution study of the

The ability of field bean protease inhibitor (FBPI) to inhibit ethylnitrosourea (ENU)-induced tumours of the nervous system of Sprague-Dawley rats was investigated. Groups of 1-day-old rats were injected intraperitoneally (i.p.) with neurocarcinogenic amounts of ENU and a few hours later, one group

Protease inhibitors (PIs), particularly the soybean-derived Bowman-Birk inhibitor, have proved to be powerful blockers of carcinogenesis in many in vitro and animal model systems. However, so far an ability of PIs to suppress gastric carcinogenesis has not been demonstrated, because of the

BACKGROUND Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. OBJECTIVE To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal

Protease inhibitors (PIs) of synthetic, bacterial or soybean origin have been shown to suppress carcinogen or radiation-induced rat mammary carcinogenesis. We report, for the first time, the effect of year-long feeding of Field bean meal, a rich source of PIs with a 24% protein content, at different

Protease inhibitor preparations (PIP) with antitryptic and antichymotryptic activities, isolated from field bean legume as well as doxorubicin and cyclophosphamide could effectively suppress the growth of Yoshida sarcoma ascites tumor cells transplanted in adult rats and prevent their death. As

A halogenated unidentified analytical response (UAR) was encountered in a number of imported Fava bean samples during the Food and Drug Administration's routine pesticide-monitoring program. Gas chromatographic/mass spectrometric (GC/MS) analyses identified the halogenated component as

Exposure to inorganic arsenic (iAs) through drinking water is a major public health concern affecting most countries. Epidemiologic studies showed a significant association between consumption of iAs through drinking water and different types of cancer. However, the exact mechanisms underlying

A nutrition survey was done in four Colombian villages situated in the rural area of Nariño, previously identified as exhibiting different levels of risk for gastric cancer and its precursor lesions. The survey was based on personal visits by trained interviewers to a random sample of families in

A lectin present in the broad bean, Vicia faba, was isolated by affinity chromatography on Sephadex G-150. The active lectin had a molecular weight of 50 000. The lectin contained about 3% neutral sugar and it contained two different subunits. The subunits had molecular weights of 17 300 and 14 300.

A single dose of 10 mg of 7,12-dimethylbenz[a]anthracene (DMBA), administered to rats through intragastric intubation, was sufficient to induce many biochemical and histopathological changes in their mammary tissue. Significant increases were observed in the activity levels of the enzymes acid

Constant consumption of broad bean (Vicia faba L.) induces intestinal inflammation and reduces growth rate in grass carp (Ctenopharyngodon idellus C. et V). However, the mechanisms underlying these effects are unclear. In mammalian models of inflammatory bowel disease (IBD), endotoxin and flagellin

Prolonged topical treatment with protease inhibitors (PIs) both synthetic and of bacterial origin have been shown to prevent carcinogen initiated and croton oil or phorbol acetate promoted skin carcinogenesis in mice. However, no one has yet examined the possibility of a purified PI of plant origin