Arm 1 (39 patients) included first the control period, followed by one-day wash-out, and then the intervention period.
Procedures for control period included providing daily bed bathing with soap and water over three consecutive days, while intervention period included daily bed bathing with 2% CHG solution over three consecutive days.

Arm 2 (39 patients) included first the intervention period, followed by one-day wash-out, and then the control period.
Procedures for control period included providing daily bed bathing with soap and water over three consecutive days, while intervention period included daily bed bathing with 2% CHG solution over three consecutive days.

MRSA Colonization

VRE Colonization

Patients were bathed from the neck down, avoiding contact with face, mucous membranes and wounds by wiping with CHG solution for each period. The patient's skin bathed in the order of clean area to dirty area. Additionally, if patients in both arms became soiled after the daily baths, contaminated body areas were wiped using water and disposable washcloths. Patients were assessed daily for localised or body-wide skin reactions.

Bed bathing with 2% CHG solution

Patients were bathed from the neck down, avoiding contact with face, mucous membranes and wounds by wiping with soap and water. The patient's skin bathed in the order of clean area to dirty area. Additionally, if patients in both arms became soiled after the daily baths, contaminated body areas were wiped using water and disposable washcloths. Patients were assessed daily for localised or body-wide skin reactions. During control period, patients were washed with soap and then rinsed with water, and dried with disposable towels

Bed bathing with soap and water

Hacettepe University

The Effect of Chlorhexidine Bathing on MRSA and VRE Colonization Among Haematology-Oncology ICU Patients

The Effect of Bathing With Chlorhexidine on MRSA and VRE Colonization in Hematology and Oncology Inpatients

Wiping baths with 2% CHG solution would have lower MRSA and/or VRE skin colonization rates with statistically significant differences compared to the soap and water baths

All IPD that underlie results will be in a publication

Gul Hatice TARAKCIOGLU CELIK

Department of Fundamentals of Nursing, Faculty of Nursing

The Scientific and Technological Research Council of Turkey

Arm 1 (39 patients) included first the control period, followed by one-day wash-out, and then the intervention period. Arm 2 (39 patients) included first the intervention period, followed by one-day wash-out, and then the control period. The first patient was assigned to the second arm after the draw, and the patients continued to take the first arm and second arm respectively. Each period lasted three consecutive days with a total of 7 days for each patient. During the period of the study, 8 patients from Arm1 and 9 patients from Arm 2 could not complete the study due to several reasons. Thus, the final sample consisted of 31 patients in Arm 1 and 30 patients in Arm 2.

Each active arm patient will be given the tested drug on admission, 30-60 minutes before the surgery, by the nurses.
2 g dose of cephalexin (or Clindamycin 600 mg for patients suffering from allergy) will be given once, orally, 30-60 minutes prior to skin lesion excision

Each placebo arm patient will be given the placebo drug on admission, 30-60 minutes before the surgery, by the nurses

Skin Lesion

The subjects will be randomized, at the operation day, to one of two treatment groups:
group 1: prophylactic antibiotic
group 2: placebo oral capsule
Sealed envelopes, numbered according to the randomization dose, containing the drug or placebo will be prepared in advance and provided to the patient following randomization.
Each patient will be given the randomized drug on admission, 30-60 minutes before the surgery, by the nurses.

Cephalexin

The subjects will be randomized, at the operation day, to one of two treatment groups:
group 1: prophylactic antibiotic
group 2: placebo
Sealed envelopes, numbered according to the randomization dose, containing the drug or placebo will be prepared in advance and provided to the patient following randomization.
Each patient will be given the randomized drug on admission, 30-60 minutes before the surgery, by the nurses.

Placebo oral capsule

Department of Plastic Surgery, Rambam Medical Center

The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions

A Randomized, Placebo Controlled Trial of the Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions

Wounds will be assessed for infection by the doctor at the time of removal of sutures, or sooner if the patient had complaints about the wound.
The definition of SSI and its classification to superficial or deep will be based on the presence of any of the following criteria that were adapted from the Centre for Disease Control and Prevention (CDC) definition for superficial SSI [42]. The primary outcome will consist of any SSI, superficial or deep.

Rambam Health Care Campus

A randomized, 1:1, double-blind, placebo controlled trial designed to evaluate the effect of prophylactic antibiotic on patients presenting for skin excision from lower limbs.
Before the surgery patient's demographics, medical history, skin lesion's site, properties and size will be documented. During the surgery the size of the wound and the sutures used will be documented. Afterwards, the wound will be assed for signs of infection (criteria adapted from the Centre for Disease Control and Prevention definition for superficial SSI [42]) and other complications during the follow-up period as needed until sutures will be removed at our clinic.

Infection, Bacterial

Antibiotic Resistant Infection

Diagnostic Self Evaluation

Meningitis, Bacterial

Nosocomial Infection

Neurosurgery dept. University Hospital

Neurosurgery department, University Hospital

Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

analyse of different body fluids to detect the focus of infections post neurosurgical fever

coagulase/悪性腫瘍

The Effect of Chlorhexidine Bathing on MRSA and VRE Colonization Among Haematology-Oncology ICU Patients

The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions

Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

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