cyclolinopeptide/過敏症

The immunosuppressive activity of a linear peptide related to cyclolinopeptide A, Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe, and its nine analogs, where each successive amino acid residue was substituted by alanine, was investigated using the plaque forming cell and delayed type hypersensitivity tests for

Cyclolinopeptide A (CLA), a cyclic natural nonapeptide isolated in 1959 from linseed oil, was found to possess the immunosuppressive activity of the range comparable to that of cyclosporin A (CS-A). The influence of CLA on the primary and secondary humoral response was determined by the

Cyclolinopeptide A, naturally occurring immunomodulatory nonapeptide, was modified with S or R-γ(3)-bis(homophenylalanine) in positions 3 or 4, or both 3 and 4. The replacement of one or both Phe residues by γ(3)-hhPhe led to decrease of their conformational flexibility in the analogues in

In connection with our discovery of a strong immunosuppressive activity of cyclolinopeptide A (CLA), we investigated immunosuppressive properties of antamanide and a number of its analogues, including symmetrical antamanide, and compared them with the activities of cyclosporin A and CLA. The