Pelvic Floor Dyssynergia

Vaginal suppository placed once daily, patients will record pelvic pain daily on a VAS scale, sexual satisfaction and quality of life on a standardized questionnaire weekly

Baclofen/diazepam

Vaginal suppository placed once daily, patient will record pelvic pain daily on a VAS scale, sexual satisfaction and quality of life on a standardized questionnaire weeky.

Vaginal placebo

Baclofen/Diazepam Supps for Treatment of Pelvic Floor Myalgia

A Randomized Double Blind Placebo Controlled Cross-over Trial of Baclofen and Diazepam Suppositories for the Management of Pelvic Floor Myalgia

The scale ranges from 0 (no pain) to 10 (worst pain ever experienced)

Self report measure of female sexual dysfunction

Ranks patients overall feeling about health from 1 (very much better) to 7 (very much worse)

Standardized self assessment tool to measure overall health status

only pooled data will be shared outside of the research team

John Thiel

Clinical Professor

Dr. John A. Thiel Medical Professional Corporation

The dose of bupivacaine given to each patient was determined by the response of the previously tested patient using a modified Dixon's up-and-down method

Perianal Surgery

using a modified Dixon's up-and-down method (using 0.5 mg as a step size) (16). The first patient was tested at a dose 1.5 mg bupivacaine, if patient responded with failed block then the next patient received an increment of 0.5mg bupivacaine, if patient responded with successful block, then the next patient received a decrement of 0.5mg bupivacaine. The research continued until we obtained seven crossover midpoints.

Dixon's up-and-down method

Minimal Effective Dose of Hyperbaric Spinal Bupivacaine for Saddle Block

The Minimal Effective Dose of Hyperbaric Spinal Bupivacaine for Successful Reliable Saddle Block for Minor Perianal Surgeries

the minimal effective dose of hyperbaric bupivacaine using a modified Dixon's up-and-down method (using 0.5 mg as a step size) (16). The first patient was tested at a dose 1.5 mg bupivacaine, if patient responded with failed block then the next patient received an increment of 0.5mg bupivacaine, if patient responded with successful block, then the next patient received a decrement of 0.5mg bupivacaine. The research continued until we obtained seven crossover midpoints.

level of sensory block scale was checked using alcohol swab throughout segmental skin dermatomes

level of motor block scale was assessed using Bormage scale by asking patient to bend his/her thigh,knees and ankles

Patient's satisfactions were evaluated with a 4-point score (0=poor, 1=good, 2=very good, 3= excellent).

Surgeon's satisfactions were evaluated with a 4-point score (0=poor, 1=good, 2=very good, 3= excellent).

Dammam University

A,1 Armodafinil Study Drug

A,2 Matching Placebo

Total

Sex: Female, Male

Region of Enrollment

This scale measures overall fatigue due to medical illness. range is 0-80 with 80 being severe fatigue

diazepam/headache

Baclofen/Diazepam Supps for Treatment of Pelvic Floor Myalgia

Minimal Effective Dose of Hyperbaric Spinal Bupivacaine for Saddle Block

An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue

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